'No allogeneic blood transfusion' protocol for the surgical correction of craniosynostoses. II. Clinical application

F. Velardi, A. Di Chirico, C. Di Rocco, C. Fundarò, O. Genovese, C. Rendeli, G. Menichella, R. Serafini, M. Piastra, L. Viola, D. Pietrini, A. Pusateri, F. Stoppa

Research output: Contribution to journalArticle

Abstract

The authors describe the results obtained in 13 consecutive cases of craniosynostosis operated on according to a protocol devised at avoiding allogeneic blood transfusion. The protocol is based on pre- and postoperative treatment with erythropoietin, preoperative autologous blood donation, preoperative normovolemic hemodilution and intraoperative blood salvage. Nine subjects were affected by simple forms of craniosynostosis, whereas the remaining 4 presented with oxycephaly or craniofacial syndromes. Five of the 13 children were under 7 months and a further 3, under 10 months of age at the time of the surgical operation. Seven children weighed less than 10 kg. Allogeneic blood transfusion was avoided in 11 of the 13 children considered. Two failures - defined as the necessity to reinfuse the patient with an allogeneic blood transfusion - were recorded, 1 of them resulting from an unexpected hemorrhage during surgery. The results obtained indicate that this protocol designed to avoid allogeneic blood transfusion can be safely applied in the great majority of children with craniosynostosis, even when the surgical correction is carried out early in life.

Original languageEnglish
Pages (from-to)732-741
Number of pages10
JournalChild's Nervous System
Volume14
Issue number12
DOIs
Publication statusPublished - 1998

Keywords

  • Allogeneic blood transfusion
  • Craniosynostosis
  • Intraoperative blood salvage

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

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    Velardi, F., Di Chirico, A., Di Rocco, C., Fundarò, C., Genovese, O., Rendeli, C., Menichella, G., Serafini, R., Piastra, M., Viola, L., Pietrini, D., Pusateri, A., & Stoppa, F. (1998). 'No allogeneic blood transfusion' protocol for the surgical correction of craniosynostoses. II. Clinical application. Child's Nervous System, 14(12), 732-741. https://doi.org/10.1007/s003810050306