No association between dopamine D2 and D4 receptor gene variants and antidepressant activity of two selective serotonin reuptake inhibitors

Alessandro Serretti, Raffaella Zanardi, Cristina Cusin, David Rossini, Roberta Lilli, Cristina Lorenzi, Enrico Lattuada, Enrico Smeraldi

Research output: Contribution to journalArticlepeer-review

Abstract

The possible association of the dopamine receptor D2 (Ser 311Cys) and D4 exon 3 (48 base pair repeat) gene variants with the antidepressant activity of selective serotonin reuptake inhibitors (SSRIs) was investigated in a sample of 364 inpatients affected by a major depressive episode treated with fluvoxamine, 300 mg/day (n=266), or paroxetine, 20-40 mg/day (n=98). The severity of depressive symptoms was assessed weekly with the Hamilton Rating Scale for Depression. Dopamine receptor D2 (DRD2) and dopamine receptor D4 (DRD4) allelic variants were determined in each subject by polymerase chain reaction. We observed that DRD2 and DRD4 variants were not associated with response to SSRI treatment. Possible stratification factors, such as sex, diagnosis, presence of psychotic features, depressive symptoms at baseline, paroxetine and fluvoxamine plasma levels, and pindolol augmentation did not significantly influence the observed results. The investigated DRD2 and DRD4 gene variants therefore do not seem to play a major role in the antidepressant activity of SSRIs, at least in the present sample.

Original languageEnglish
Pages (from-to)195-203
Number of pages9
JournalPsychiatry Research
Volume104
Issue number3
DOIs
Publication statusPublished - Nov 30 2001

Keywords

  • Antidepressant treatment
  • Fluvoxamine
  • Mood disorders
  • Paroxetine
  • Pharmacogenetics
  • Pindolol

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)

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