No association between eating disorders, obsessive-compulsive disorder and 1438G/A 5-HT2A promoter polymorphism in an Italian population

D. Di Bella, M. C. Cavallini, C. Riboldi, M. Manzato, L. Bellodi

Research output: Contribution to journalArticlepeer-review

Abstract

Eating Disorders (ED), including Anorexia Nervosa (AN) and Bulimia Nervosa (BN), are a group of psychiatric syndromes characterized by severe disturbances of eating behavior, for which a common etiopathological background has been proposed. Familial and twin studies support the presence of a strong genetic component. ED have been considered to belong to obsessive-compulsive spectrum. Obsessive-compulsive features are common in ED and it is possible to hypothesize a common genetic liability for both diseases. Recently an association has been reported between the -1438 G/A polymorphism in the promoter region of the gene coding for the serotonin receptor 5-HT2A and both AN and OCD. We compared the distribution of 5-HT2A alleles and genotypes in a sample of 103 ED patients (53 AN and 50 BN), diagnosed according with DSM IV criteria, and 83 healthy controls: no genotypic and allelic association was found. These results have, in a preliminary way, been confirmed in a 32 ED trios sample HRR analysis in a sample of 70 nuclear families of OCD probands (40 males, 30 females) produced negative results. Our study failed to confirm the previous finding of an association between the -1438G/ A 5-HT2A polymorphism and both ED and OCD in our Italian population.

Original languageEnglish
Pages (from-to)501-502
Number of pages2
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Volume96
Issue number4
Publication statusPublished - Aug 7 2000

ASJC Scopus subject areas

  • Genetics(clinical)
  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)

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