No association between genetic markers in BDNF gene and lithium prophylaxis in a Greek sample

Antonio Drago, Alessandro Serretti, Rebecca Smith, Patricia Huezo-Diaz, Petros Malitas, Diego Albani, Diana De Ronchi, Chi Un Pae, Katherine J. Aitchison

Research output: Contribution to journalArticle

Abstract

Lithium efficacy is, at least partially, under genetic control. We investigated the association between markers in BDNF and lithium prophylactic efficacy. A set of 10 SNPs within BDNF were genotyped in a sample of 83 bipolar patients. Response to lithium was assessed by presence or absence of any illness phases during a period of 3 years of longitudinal observation. No significant association was detected between the genetic variants tested in BDNF and lithium prophylaxis. Despite the negative association, limitations including small sample size suggest that larger scale genetic associations studies of these genes and lithium prophylaxis are nonetheless indicated.

Original languageEnglish
Pages (from-to)154-157
Number of pages4
JournalInternational Journal of Psychiatry in Clinical Practice
Volume14
Issue number2
DOIs
Publication statusPublished - 2010

Keywords

  • BDNF
  • Bipolar disorder
  • Genes
  • Lithium
  • Prevention and control

ASJC Scopus subject areas

  • Psychiatry and Mental health

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    Drago, A., Serretti, A., Smith, R., Huezo-Diaz, P., Malitas, P., Albani, D., Ronchi, D. D., Pae, C. U., & Aitchison, K. J. (2010). No association between genetic markers in BDNF gene and lithium prophylaxis in a Greek sample. International Journal of Psychiatry in Clinical Practice, 14(2), 154-157. https://doi.org/10.3109/13651501003706717