No association between obsessive-compulsive disorder and the 5-HT1Dβ receptor gene

Daniela Di Bella, Maria Cristina Cavallini, Laura Bellodi

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: Serotonin abnormalities may be involved in the etiopathogenesis of obsessive-compulsive disorder (OCD). The silent G-to-C substitution at nucleotide 861 of the coding region of the 5-HT1Dβ receptor gene may be associated with liability to OCD. The aim of this study was to investigate this association in an Italian OCD study group. Method: Genotypingfor 5-HT1Dβ was performed for 79 nuclear families of probands with OCD. The transmission/disequilibrium test was used to determine transmission of the alleles from parents to offspring. Results: Of the 79 families, 48 were informative for the analysis, i.e., both parents were genotyped for 5-HT1Dβ, and at least one parent was heterozygous. No preferential transmission of either allele of the 5-HT1Dβ gene was observed. Conclusions: These data do not support a role for the 5-HT1Dβ receptor gene in conferring susceptibility to OCD.

Original languageEnglish
Pages (from-to)1783-1785
Number of pages3
JournalAmerican Journal of Psychiatry
Volume159
Issue number10
DOIs
Publication statusPublished - Oct 1 2002

ASJC Scopus subject areas

  • Psychiatry and Mental health

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