No association between serotonin-2A receptor gene polymorphism and psychotic symptomatology of mood disorders

Alessandro Serretti, Roberta Lilli, Cristina Lorenzi, Enrico Smeraldi

Research output: Contribution to journalArticlepeer-review

Abstract

Abnormalities of the serotonergic system are involved in the pathophysiology of mood disorders. In the present study, we investigated the possible influence of the T102C polymorphism of the serotonin-2A receptor gene (5-HT2A, 13q14-21) on the symptomatology of mood disorders. Inpatients affected by mood disorders (n=246, 149 bipolar, 97 major depressive disorder) were assessed with a checklist of operational criteria for psychotic illness (OPCRIT) to score their lifetime psychotic symptomatology. The subjects were also typed for 5-HT2A variants using polymerase chain reaction techniques. No association was found between this polymorphism and psychopathology as defined by the four symptomatologic factors used in phenotype definition (mania, depression, delusion and disorganization). Genetic variation at the 5-HT2A receptor gene does not, therefore, appear to play a major role in the pathogenesis of major mood disorders. Copyright (C) 1997 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)203-209
Number of pages7
JournalPsychiatry Research
Volume86
Issue number3
DOIs
Publication statusPublished - Jun 30 1999

Keywords

  • Bipolar disorder
  • Delusions
  • Disorganization
  • Genetics
  • Major depressive disorder

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)

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