No Association of a Set of Candidate Genes on Haloperidol Side Effects

Antonio Drago, Ina Giegling, Martin Schäfer, Annette M. Hartmann, Hans Jürgen Möller, Diana de Ronchi, Hans H. Stassen, Alessandro Serretti, Dan Rujescu

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We previously investigated a sample of patients during an active phase of psychosis in the search for genetic predictors of haloperidol induced side effects. In the present work we extend the genetic association analysis to a wider panel of genetic variations, including 508 variations located in 96 genes. The original sample included 96 patients. An independent group of 357 patients from the CATIE study served as a replication sample. Outcomes in the investigation sample were the variation through time of: 1) the ESRS and UKU total scores 2) ESRS and UKU subscales (neurologic and psychic were included) related to tremors and 3) ESRS and UKU subscales that do not relate to tremors. Outcome in the replication sample was the presence vs absence of motoric side effects from baseline to visit 1 (~ one month of treatment) as assessed by the AIMS scale test. Rs2242480 located in the CYP3A4 was associated with a different distribution of the UKU neurologic scores through time (permutated p = 0.047) along with a trend for a different haloperidol plasma levels (lower in CC subjects). This finding was not replicated in the CATIE sample. In conclusion, we did not find conclusive evidence for a major association between the investigated variations and haloperidol induced motoric side effects.

Original languageEnglish
Article numbere44853
JournalPLoS One
Volume7
Issue number10
DOIs
Publication statusPublished - Oct 15 2012

Fingerprint

haloperidol
Haloperidol
Genes
adverse effects
Tremor
Nervous System
Cytochrome P-450 CYP3A
genes
nervous system
sampling
Psychotic Disorders
Plasmas
genetic variation
Therapeutics

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Drago, A., Giegling, I., Schäfer, M., Hartmann, A. M., Möller, H. J., de Ronchi, D., ... Rujescu, D. (2012). No Association of a Set of Candidate Genes on Haloperidol Side Effects. PLoS One, 7(10), [e44853]. https://doi.org/10.1371/journal.pone.0044853

No Association of a Set of Candidate Genes on Haloperidol Side Effects. / Drago, Antonio; Giegling, Ina; Schäfer, Martin; Hartmann, Annette M.; Möller, Hans Jürgen; de Ronchi, Diana; Stassen, Hans H.; Serretti, Alessandro; Rujescu, Dan.

In: PLoS One, Vol. 7, No. 10, e44853, 15.10.2012.

Research output: Contribution to journalArticle

Drago, A, Giegling, I, Schäfer, M, Hartmann, AM, Möller, HJ, de Ronchi, D, Stassen, HH, Serretti, A & Rujescu, D 2012, 'No Association of a Set of Candidate Genes on Haloperidol Side Effects', PLoS One, vol. 7, no. 10, e44853. https://doi.org/10.1371/journal.pone.0044853
Drago A, Giegling I, Schäfer M, Hartmann AM, Möller HJ, de Ronchi D et al. No Association of a Set of Candidate Genes on Haloperidol Side Effects. PLoS One. 2012 Oct 15;7(10). e44853. https://doi.org/10.1371/journal.pone.0044853
Drago, Antonio ; Giegling, Ina ; Schäfer, Martin ; Hartmann, Annette M. ; Möller, Hans Jürgen ; de Ronchi, Diana ; Stassen, Hans H. ; Serretti, Alessandro ; Rujescu, Dan. / No Association of a Set of Candidate Genes on Haloperidol Side Effects. In: PLoS One. 2012 ; Vol. 7, No. 10.
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