No association of DNA ligase-I polymorphism with the risk of lung cancer in North-Indian population

Ranbir Chander Sobti, Pushpinder Kaur, Satinder Kaur, Ashok Kumar Janmeja, Surinder Kumar Jindal, Jai Kishan, Sara Raimondi

Research output: Contribution to journalArticlepeer-review

Abstract

DNA ligases play an essential role in repair, replication, and recombination of DNA, and catalyzes the formation of a phosphodiester bond at a nick junction on single- and double-strand breaks. We have conducted a hospital-based case-control study to examine the role of polymorphism of DNA repair gene ligase I (LIGI) in the context of lung cancer risk for north Indian population. One hundred, fifty-one primary lung cancer cases and an equal number of matching hospital controls were collected. The LIGI polymorphism was determined by using the PCR-RFLP method. The association between polymorphisms in the LIGI gene with the risk of lung cancer was estimated by computing odds ratios (ORs) and a 95% confidence interval (CI) using a Multivariate Logistic Regression Analysis. The risk for lung cancer was not associated for individuals featuring LIGI (AC) (OR -0.8, 95% CI = 0.44-1.40) and (AA) (OR -0.8, 95% CI = 0.41-1.80) genotypes. The DNA repair gene (LIGI) may not be playing an important role in modulating the risk of lung cancer in the north Indian population.

Original languageEnglish
Pages (from-to)484-489
Number of pages6
JournalDNA and Cell Biology
Volume25
Issue number8
DOIs
Publication statusPublished - Aug 2006

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cell Biology

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