No association of DPP6 with amyotrophic lateral sclerosis in an Italian population

Isabella Fogh, Sandra D'Alfonso, Cinzia Gellera, Antonia Ratti, Cristina Cereda, Silvana Penco, Lucia Corrado, Gianni Sorar, Barbara Castellotti, Cinzia Tiloca, Stella Gagliardi, Lorena Cozzi, Michelle K. Lupton, Nicola Ticozzi, Letizia Mazzini, Chris E. Shaw, Ammar Al-Chalabi, John Powell, Vincenzo Silani

Research output: Contribution to journalArticlepeer-review


We have attempted to replicate a recently reported association of polymorphism rs10260404, in the Dipeptidyl-peptidase 6 gene (DPP6), with susceptibility to amyotrophic lateral sclerosis (ALS) in a large independent Italian cohort of 904 cases and 1036 controls. Minor allele frequency was 0.38 in cases and 0.39 in controls and no evidence of association with ALS was observed (P= 0.638). Our negative results agree with those recently reported in additional Polish and Italian cohorts.

Original languageEnglish
Pages (from-to)966-967
Number of pages2
JournalNeurobiology of Aging
Issue number5
Publication statusPublished - May 2011


  • Amyotrophic lateral sclerosis
  • Dipeptidyl-peptidase 6 (DPP6) gene
  • Genome-wide association study
  • Polymorphism

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Ageing
  • Developmental Biology
  • Geriatrics and Gerontology


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