No association of DPP6 with amyotrophic lateral sclerosis in an Italian population

Isabella Fogh, Sandra D'Alfonso, Cinzia Gellera, Antonia Ratti, Cristina Cereda, Silvana Penco, Lucia Corrado, Gianni Sorar, Barbara Castellotti, Cinzia Tiloca, Stella Gagliardi, Lorena Cozzi, Michelle K. Lupton, Nicola Ticozzi, Letizia Mazzini, Chris E. Shaw, Ammar Al-Chalabi, John Powell, Vincenzo Silani

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

We have attempted to replicate a recently reported association of polymorphism rs10260404, in the Dipeptidyl-peptidase 6 gene (DPP6), with susceptibility to amyotrophic lateral sclerosis (ALS) in a large independent Italian cohort of 904 cases and 1036 controls. Minor allele frequency was 0.38 in cases and 0.39 in controls and no evidence of association with ALS was observed (P= 0.638). Our negative results agree with those recently reported in additional Polish and Italian cohorts.

Original languageEnglish
Pages (from-to)966-967
Number of pages2
JournalNeurobiology of Aging
Volume32
Issue number5
DOIs
Publication statusPublished - May 2011

Fingerprint

Dipeptidyl-Peptidases and Tripeptidyl-Peptidases
Amyotrophic Lateral Sclerosis
Gene Frequency
Population
Genes

Keywords

  • Amyotrophic lateral sclerosis
  • Dipeptidyl-peptidase 6 (DPP6) gene
  • Genome-wide association study
  • Polymorphism

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Ageing
  • Developmental Biology
  • Geriatrics and Gerontology

Cite this

No association of DPP6 with amyotrophic lateral sclerosis in an Italian population. / Fogh, Isabella; D'Alfonso, Sandra; Gellera, Cinzia; Ratti, Antonia; Cereda, Cristina; Penco, Silvana; Corrado, Lucia; Sorar, Gianni; Castellotti, Barbara; Tiloca, Cinzia; Gagliardi, Stella; Cozzi, Lorena; Lupton, Michelle K.; Ticozzi, Nicola; Mazzini, Letizia; Shaw, Chris E.; Al-Chalabi, Ammar; Powell, John; Silani, Vincenzo.

In: Neurobiology of Aging, Vol. 32, No. 5, 05.2011, p. 966-967.

Research output: Contribution to journalArticle

Fogh, I, D'Alfonso, S, Gellera, C, Ratti, A, Cereda, C, Penco, S, Corrado, L, Sorar, G, Castellotti, B, Tiloca, C, Gagliardi, S, Cozzi, L, Lupton, MK, Ticozzi, N, Mazzini, L, Shaw, CE, Al-Chalabi, A, Powell, J & Silani, V 2011, 'No association of DPP6 with amyotrophic lateral sclerosis in an Italian population', Neurobiology of Aging, vol. 32, no. 5, pp. 966-967. https://doi.org/10.1016/j.neurobiolaging.2009.05.014
Fogh, Isabella ; D'Alfonso, Sandra ; Gellera, Cinzia ; Ratti, Antonia ; Cereda, Cristina ; Penco, Silvana ; Corrado, Lucia ; Sorar, Gianni ; Castellotti, Barbara ; Tiloca, Cinzia ; Gagliardi, Stella ; Cozzi, Lorena ; Lupton, Michelle K. ; Ticozzi, Nicola ; Mazzini, Letizia ; Shaw, Chris E. ; Al-Chalabi, Ammar ; Powell, John ; Silani, Vincenzo. / No association of DPP6 with amyotrophic lateral sclerosis in an Italian population. In: Neurobiology of Aging. 2011 ; Vol. 32, No. 5. pp. 966-967.
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