No association of HIV type 1 long terminal repeat sequence pattern with long-term nonprogression and in vivo viral replication levels in European subjects

Ubaldo Visco-Comandini, Zhibing Yun, Anders Vahlne, Anders Sönnerborg

Research output: Contribution to journalArticlepeer-review

Abstract

The HIV-1 long terminal repeat (LTR) promotes and modulates proviral transcription in the infected cell. It has been suggested that truncations and even point mutations in functional sites of the LTR are associated with low vital replication and attenuated pathogenesis in HIV-1-infected long- term nonprogressors (LTNPs). We performed a detailed analysis of LTR sequences from proviral DNA of 21 Italian and Swedish, well-characterized LTNPs and of 15 progressor patients. No truncation was found and no correlation was identified between specific LTR mutations and disease progression. We also failed to find a significant correlation between phylogenetic distance and clinical status. Although HIV-1 LTR interpatient heterogeneity among LTNPs and subjects with HIV-1 RNA levels

Original languageEnglish
Pages (from-to)609-617
Number of pages9
JournalAIDS Research and Human Retroviruses
Volume15
Issue number7
DOIs
Publication statusPublished - May 1 1999

ASJC Scopus subject areas

  • Immunology
  • Virology

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