Abstract
The HIV-1 long terminal repeat (LTR) promotes and modulates proviral transcription in the infected cell. It has been suggested that truncations and even point mutations in functional sites of the LTR are associated with low vital replication and attenuated pathogenesis in HIV-1-infected long- term nonprogressors (LTNPs). We performed a detailed analysis of LTR sequences from proviral DNA of 21 Italian and Swedish, well-characterized LTNPs and of 15 progressor patients. No truncation was found and no correlation was identified between specific LTR mutations and disease progression. We also failed to find a significant correlation between phylogenetic distance and clinical status. Although HIV-1 LTR interpatient heterogeneity among LTNPs and subjects with HIV-1 RNA levels
| Original language | English |
|---|---|
| Pages (from-to) | 609-617 |
| Number of pages | 9 |
| Journal | AIDS Research and Human Retroviruses |
| Volume | 15 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - May 1 1999 |
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ASJC Scopus subject areas
- Immunology
- Virology
Cite this
No association of HIV type 1 long terminal repeat sequence pattern with long-term nonprogression and in vivo viral replication levels in European subjects. / Visco-Comandini, Ubaldo; Yun, Zhibing; Vahlne, Anders; Sönnerborg, Anders.
In: AIDS Research and Human Retroviruses, Vol. 15, No. 7, 01.05.1999, p. 609-617.Research output: Contribution to journal › Article
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TY - JOUR
T1 - No association of HIV type 1 long terminal repeat sequence pattern with long-term nonprogression and in vivo viral replication levels in European subjects
AU - Visco-Comandini, Ubaldo
AU - Yun, Zhibing
AU - Vahlne, Anders
AU - Sönnerborg, Anders
PY - 1999/5/1
Y1 - 1999/5/1
N2 - The HIV-1 long terminal repeat (LTR) promotes and modulates proviral transcription in the infected cell. It has been suggested that truncations and even point mutations in functional sites of the LTR are associated with low vital replication and attenuated pathogenesis in HIV-1-infected long- term nonprogressors (LTNPs). We performed a detailed analysis of LTR sequences from proviral DNA of 21 Italian and Swedish, well-characterized LTNPs and of 15 progressor patients. No truncation was found and no correlation was identified between specific LTR mutations and disease progression. We also failed to find a significant correlation between phylogenetic distance and clinical status. Although HIV-1 LTR interpatient heterogeneity among LTNPs and subjects with HIV-1 RNA levels
AB - The HIV-1 long terminal repeat (LTR) promotes and modulates proviral transcription in the infected cell. It has been suggested that truncations and even point mutations in functional sites of the LTR are associated with low vital replication and attenuated pathogenesis in HIV-1-infected long- term nonprogressors (LTNPs). We performed a detailed analysis of LTR sequences from proviral DNA of 21 Italian and Swedish, well-characterized LTNPs and of 15 progressor patients. No truncation was found and no correlation was identified between specific LTR mutations and disease progression. We also failed to find a significant correlation between phylogenetic distance and clinical status. Although HIV-1 LTR interpatient heterogeneity among LTNPs and subjects with HIV-1 RNA levels
UR - http://www.scopus.com/inward/record.url?scp=0033135516&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033135516&partnerID=8YFLogxK
U2 - 10.1089/088922299310908
DO - 10.1089/088922299310908
M3 - Article
C2 - 10331439
AN - SCOPUS:0033135516
VL - 15
SP - 609
EP - 617
JO - AIDS Research and Human Retroviruses
JF - AIDS Research and Human Retroviruses
SN - 0889-2229
IS - 7
ER -