No association of IFI16 (interferon-inducible protein 16) variants with susceptibility to multiple sclerosis

Research output: Contribution to journalArticle

Abstract

IFI16 encodes a nucleic acid-sensor which detects latent EBV and triggers inflammasome activation. We analysed IFI16 variants in two multiple sclerosis (MS) case-control cohorts from Italy and Spain; results were combined with a previous study. A risk variant for celiac disease/rheumatoid arthritis, a polymorphic exon 7 duplication, and a copy number variant (CNV) in the 5' region were genotyped. No significant association was detected, although heterogeneity was noted for the 5' CNV in the Italian plus GeneMSA cohorts and the Spanish sample. Thus, IFI16 variants do not contribute to MS susceptibility, although some heterogeneity may exist for the 5' CNV.

Original languageEnglish
Pages (from-to)49-52
Number of pages4
JournalJournal of Neuroimmunology
Volume271
Issue number1-2
DOIs
Publication statusPublished - 2014

Fingerprint

Interferons
Multiple Sclerosis
Inflammasomes
Proteins
Celiac Disease
Human Herpesvirus 4
Spain
Nucleic Acids
Italy
Exons
Rheumatoid Arthritis

Keywords

  • EBV infection
  • Genetic susceptibility
  • IFI16 (interferon-inducible protein 16)
  • Multiple sclerosis

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

Cite this

@article{c8355e2903bc43e881385b05a5573583,
title = "No association of IFI16 (interferon-inducible protein 16) variants with susceptibility to multiple sclerosis",
abstract = "IFI16 encodes a nucleic acid-sensor which detects latent EBV and triggers inflammasome activation. We analysed IFI16 variants in two multiple sclerosis (MS) case-control cohorts from Italy and Spain; results were combined with a previous study. A risk variant for celiac disease/rheumatoid arthritis, a polymorphic exon 7 duplication, and a copy number variant (CNV) in the 5' region were genotyped. No significant association was detected, although heterogeneity was noted for the 5' CNV in the Italian plus GeneMSA cohorts and the Spanish sample. Thus, IFI16 variants do not contribute to MS susceptibility, although some heterogeneity may exist for the 5' CNV.",
keywords = "EBV infection, Genetic susceptibility, IFI16 (interferon-inducible protein 16), Multiple sclerosis",
author = "Guerini, {Franca R.} and Mario Clerici and Rachele Cagliani and Sunny Malhotra and Xavier Montalban and Diego Forni and Cristina Agliardi and Stefania Riva and Domenico Caputo and Daniela Galimberti and Rosanna Asselta and Chiara Fenoglio and Elio Scarpini and Comi, {Giacomo P.} and Nereo Bresolin and Manuel Comabella and Manuela Sironi",
year = "2014",
doi = "10.1016/j.jneuroim.2014.04.006",
language = "English",
volume = "271",
pages = "49--52",
journal = "Journal of Neuroimmunology",
issn = "0165-5728",
publisher = "Elsevier Science B.V.",
number = "1-2",

}

TY - JOUR

T1 - No association of IFI16 (interferon-inducible protein 16) variants with susceptibility to multiple sclerosis

AU - Guerini, Franca R.

AU - Clerici, Mario

AU - Cagliani, Rachele

AU - Malhotra, Sunny

AU - Montalban, Xavier

AU - Forni, Diego

AU - Agliardi, Cristina

AU - Riva, Stefania

AU - Caputo, Domenico

AU - Galimberti, Daniela

AU - Asselta, Rosanna

AU - Fenoglio, Chiara

AU - Scarpini, Elio

AU - Comi, Giacomo P.

AU - Bresolin, Nereo

AU - Comabella, Manuel

AU - Sironi, Manuela

PY - 2014

Y1 - 2014

N2 - IFI16 encodes a nucleic acid-sensor which detects latent EBV and triggers inflammasome activation. We analysed IFI16 variants in two multiple sclerosis (MS) case-control cohorts from Italy and Spain; results were combined with a previous study. A risk variant for celiac disease/rheumatoid arthritis, a polymorphic exon 7 duplication, and a copy number variant (CNV) in the 5' region were genotyped. No significant association was detected, although heterogeneity was noted for the 5' CNV in the Italian plus GeneMSA cohorts and the Spanish sample. Thus, IFI16 variants do not contribute to MS susceptibility, although some heterogeneity may exist for the 5' CNV.

AB - IFI16 encodes a nucleic acid-sensor which detects latent EBV and triggers inflammasome activation. We analysed IFI16 variants in two multiple sclerosis (MS) case-control cohorts from Italy and Spain; results were combined with a previous study. A risk variant for celiac disease/rheumatoid arthritis, a polymorphic exon 7 duplication, and a copy number variant (CNV) in the 5' region were genotyped. No significant association was detected, although heterogeneity was noted for the 5' CNV in the Italian plus GeneMSA cohorts and the Spanish sample. Thus, IFI16 variants do not contribute to MS susceptibility, although some heterogeneity may exist for the 5' CNV.

KW - EBV infection

KW - Genetic susceptibility

KW - IFI16 (interferon-inducible protein 16)

KW - Multiple sclerosis

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U2 - 10.1016/j.jneuroim.2014.04.006

DO - 10.1016/j.jneuroim.2014.04.006

M3 - Article

VL - 271

SP - 49

EP - 52

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

SN - 0165-5728

IS - 1-2

ER -