No association of IFI16 (interferon-inducible protein 16) variants with susceptibility to multiple sclerosis

Franca R. Guerini, Mario Clerici, Rachele Cagliani, Sunny Malhotra, Xavier Montalban, Diego Forni, Cristina Agliardi, Stefania Riva, Domenico Caputo, Daniela Galimberti, Rosanna Asselta, Chiara Fenoglio, Elio Scarpini, Giacomo P. Comi, Nereo Bresolin, Manuel Comabella, Manuela Sironi

Research output: Contribution to journalArticlepeer-review

Abstract

IFI16 encodes a nucleic acid-sensor which detects latent EBV and triggers inflammasome activation. We analysed IFI16 variants in two multiple sclerosis (MS) case-control cohorts from Italy and Spain; results were combined with a previous study. A risk variant for celiac disease/rheumatoid arthritis, a polymorphic exon 7 duplication, and a copy number variant (CNV) in the 5' region were genotyped. No significant association was detected, although heterogeneity was noted for the 5' CNV in the Italian plus GeneMSA cohorts and the Spanish sample. Thus, IFI16 variants do not contribute to MS susceptibility, although some heterogeneity may exist for the 5' CNV.

Original languageEnglish
Pages (from-to)49-52
Number of pages4
JournalJournal of Neuroimmunology
Volume271
Issue number1-2
DOIs
Publication statusPublished - 2014

Keywords

  • EBV infection
  • Genetic susceptibility
  • IFI16 (interferon-inducible protein 16)
  • Multiple sclerosis

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

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