No association of the Ser/Cys311 DRD2 molecular variant with schizophrenia using a classical case control study and the haplotype relative risk

Massimiliano Verga, Fabio Macciardi, Silvia Pedrini, Susanna Cohen, Enrico Smeraldi

Research output: Contribution to journalArticlepeer-review

Abstract

Arinami et al. (1994) reported an association between the Ser311/Cys311 variant of the DRD2 gene and schizophrenia in a Japanese population. We did not find statistically significant differences in the distribution of the allele frequencies between schizophrenics (103) and controls (97) in a case- control sample (χ 2 = 2.07; p = 0.150) or in 64 nuclear families with the haplotype relative risk (HRR) design (χ 2 = 0.13; p=0.718). Our results seem to exclude a main involvement of this variant of the dopamine D2 receptor gene in the etiopathogenesis of schizophrenia.

Original languageEnglish
Pages (from-to)117-121
Number of pages5
JournalSchizophrenia Research
Volume25
Issue number2
DOIs
Publication statusPublished - May 24 1997

Keywords

  • Association study
  • Dopamine D2 receptor gene
  • Haplotype relative risk
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Behavioral Neuroscience
  • Biological Psychiatry
  • Neurology
  • Psychology(all)

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