No association of the Ser/Cys311 DRD2 molecular variant with schizophrenia using a classical case control study and the haplotype relative risk

Massimiliano Verga, Fabio Macciardi, Silvia Pedrini, Susanna Cohen, Enrico Smeraldi

Research output: Contribution to journal › Article

Abstract

Arinami et al. (1994) reported an association between the Ser311/Cys311 variant of the DRD2 gene and schizophrenia in a Japanese population. We did not find statistically significant differences in the distribution of the allele frequencies between schizophrenics (103) and controls (97) in a case- control sample (χ 2 = 2.07; p = 0.150) or in 64 nuclear families with the haplotype relative risk (HRR) design (χ 2 = 0.13; p=0.718). Our results seem to exclude a main involvement of this variant of the dopamine D2 receptor gene in the etiopathogenesis of schizophrenia.

Original languageEnglish
Pages (from-to)117-121
Number of pages5
JournalSchizophrenia Research
Volume25
Issue number2
DOIs
Publication statusPublished - May 24 1997

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Haplotypes
Case-Control Studies
Schizophrenia
Dopamine D2 Receptors
Nuclear Family
Gene Frequency
Genes
Population

Keywords

  • Association study
  • Dopamine D2 receptor gene
  • Haplotype relative risk
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Behavioral Neuroscience
  • Biological Psychiatry
  • Neurology
  • Psychology(all)

Cite this

No association of the Ser/Cys311 DRD2 molecular variant with schizophrenia using a classical case control study and the haplotype relative risk. / Verga, Massimiliano; Macciardi, Fabio; Pedrini, Silvia; Cohen, Susanna; Smeraldi, Enrico.

In: Schizophrenia Research, Vol. 25, No. 2, 24.05.1997, p. 117-121.

Research output: Contribution to journal › Article

Verga, M, Macciardi, F, Pedrini, S, Cohen, S & Smeraldi, E 1997, 'No association of the Ser/Cys311 DRD2 molecular variant with schizophrenia using a classical case control study and the haplotype relative risk', Schizophrenia Research, vol. 25, no. 2, pp. 117-121. https://doi.org/10.1016/S0920-9964(97)00013-3
Verga M, Macciardi F, Pedrini S, Cohen S, Smeraldi E. No association of the Ser/Cys311 DRD2 molecular variant with schizophrenia using a classical case control study and the haplotype relative risk. Schizophrenia Research. 1997 May 24;25(2):117-121. https://doi.org/10.1016/S0920-9964(97)00013-3
Verga, Massimiliano ; Macciardi, Fabio ; Pedrini, Silvia ; Cohen, Susanna ; Smeraldi, Enrico. / No association of the Ser/Cys311 DRD2 molecular variant with schizophrenia using a classical case control study and the haplotype relative risk. In: Schizophrenia Research. 1997 ; Vol. 25, No. 2. pp. 117-121.
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