TY - JOUR
T1 - No causal association identified for human papillomavirus infections in lung cancer
AU - Anantharaman, Devasena
AU - Gheit, Tarik
AU - Waterboer, Tim
AU - Halec, Gordana
AU - Carreira, Christine
AU - Abedi-Ardekani, Behnoush
AU - McKay-Chopin, Sandrine
AU - Zaridze, David
AU - Mukeria, Anush
AU - Szeszenia-Dabrowska, Neonila
AU - Lissowska, Jolanta
AU - Mates, Dana
AU - Janout, Vladimir
AU - Foretova, Lenka
AU - Bencko, Vladimir
AU - Rudnai, Peter
AU - Fabianova, Eleonora
AU - Tjønneland, Anne
AU - Travis, Ruth C.
AU - Boeing, Heiner
AU - Ram̊on Quir̊os, J.
AU - Johansson, Mikael
AU - Krogh, Vittorio
AU - Bas Bueno-De-Mesquita, H.
AU - Kotanidou, Anastasia
AU - Clavel-Chapelon, Fraņcoise
AU - Weiderpass, Elisabete
AU - Johansson, Mattias
AU - Pawlita, Michael
AU - Scelo, Ghislaine
AU - Tommasino, Massimo
AU - Brennan, Paul
PY - 2014/7/1
Y1 - 2014/7/1
N2 - Human papillomavirus (HPV) infections have been implicated in lung carcinogenesis, but causal associations remain uncertain. We evaluated a potential causal role for HPV infections in lung cancer through an analysis involving serology, tumor DNA, RNA, and p16 protein expression. Association between type-specific HPV antibodies and risk of lung cancer was examined among 3,083 cases and 4,328 controls in two case-control studies (retrospective) and one nested case-control study (prospective design). Three hundred and thirty-four available tumors were subjected to pathologic evaluation and subsequent HPV genotyping following stringent conditions to detect all high-risk and two low-riskHPVtypes. AllHPVDNA-positive tumors were further tested for the expression of p16 protein and type-specific HPV mRNA. On the basis of the consistency of the results, although HPV11 and HPV31 E6 antibodies were associated with lung cancer risk in the retrospective study, no association was observed in the prospective design. Presence of type-specific antibodies correlated poorly with the presence of the corresponding HPVDNAin the tumor. Although nearly 10% of the lung tumors were positive for any HPVDNA (7% for HPV16 DNA), none expressed the viral oncogenes. No association was observed between HPV antibodies or DNA and lung cancer survival. In conclusion, we found no supportive evidence for the hypothesized causal association between HPV infections and lung cancer.
AB - Human papillomavirus (HPV) infections have been implicated in lung carcinogenesis, but causal associations remain uncertain. We evaluated a potential causal role for HPV infections in lung cancer through an analysis involving serology, tumor DNA, RNA, and p16 protein expression. Association between type-specific HPV antibodies and risk of lung cancer was examined among 3,083 cases and 4,328 controls in two case-control studies (retrospective) and one nested case-control study (prospective design). Three hundred and thirty-four available tumors were subjected to pathologic evaluation and subsequent HPV genotyping following stringent conditions to detect all high-risk and two low-riskHPVtypes. AllHPVDNA-positive tumors were further tested for the expression of p16 protein and type-specific HPV mRNA. On the basis of the consistency of the results, although HPV11 and HPV31 E6 antibodies were associated with lung cancer risk in the retrospective study, no association was observed in the prospective design. Presence of type-specific antibodies correlated poorly with the presence of the corresponding HPVDNAin the tumor. Although nearly 10% of the lung tumors were positive for any HPVDNA (7% for HPV16 DNA), none expressed the viral oncogenes. No association was observed between HPV antibodies or DNA and lung cancer survival. In conclusion, we found no supportive evidence for the hypothesized causal association between HPV infections and lung cancer.
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U2 - 10.1158/0008-5472.CAN-13-3548
DO - 10.1158/0008-5472.CAN-13-3548
M3 - Article
C2 - 24760422
AN - SCOPUS:84903973448
VL - 74
SP - 3525
EP - 3534
JO - Journal of Cancer Research
JF - Journal of Cancer Research
SN - 0008-5472
IS - 13
ER -