No difference in intestinal strontium absorption after an oral or an intravenous 1,25(OH)2D3 bolus in normal subjects

M. L. Bianchi, Gianluigi Ardissino, C. P. Schmitt, V. Daccó, L. Barletta, A. Claris-Appiani, O. Mehls

Research output: Contribution to journalArticlepeer-review

Abstract

It has been suggested that 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) stimulates intestinal calcium absorption less via the intravenous (iv) than the oral route, because the first avoids direct contact of the drug with the enterocytes. However, no study has addressed the issue directly. This investigation was designed to measure the effect of a single oral or iv dose of 1,25(OH)2D3 on calcium absorption, using stable strontium (Sr) as a surrogate for calcium, and measuring the Sr fractional absorbed dose (FAD%) over 240 minutes after Sr administration. In 10 healthy volunteers, five tests were performed in a cross-over design, with a wash-out period between two consecutive tests: Sr absorption without 1,25(OH)2D3 (test A); Sr absorption immediately after either oral (test B) or iv (test C) 1,25(OH)2D3 (1.5 μMg/m2 of body surface area [BSA]); Sr absorption (24 hr after either oral (test D) or iv (test E) 1,25(OH)2D3 (1.5 μg/m2 BSA). The concurrent administration of 1,25(OH)2D3 and Sr (tests B and C) did not significantly change the area under the Sr FAD%-time curve with respect to test A (test A: 4090 ± 345; test B: 4510 ± 345; test C: 4210 ± 345), whereas Sr absorption was significantly increased (p <0.001) when Sr was given 24 hr after either oral or iv 1,25(OH)2D3 (test D: 5710 ± 345; test E: 5510 ± 345). It was concluded that 1,25(OH)2D3 is likely to influence calcium absorption significantly only via its genomic effect, independent of its administration route.

Original languageEnglish
Pages (from-to)1789-1795
Number of pages7
JournalJournal of Bone and Mineral Research
Volume14
Issue number10
DOIs
Publication statusPublished - 1999

ASJC Scopus subject areas

  • Surgery

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