No evidence for allelic association of serotonin 2A receptor and transporter gene polymorphisms with depression in Alzheimer disease

D. Micheli, C. Bonvicini, A. Rocchi, R. Ceravolo, Michelangelo Mancuso, G. Tognoni, M. Gennarelli, G. Siciliano, L. Murri

Research output: Contribution to journalArticlepeer-review

Abstract

Patients with Alzheimer disease (AD) often exhibit psychiatric symptoms associated with cognitive impairment. The serotoninergic system may be involved in the development of depressive symptoms in AD patients, as suggested by the evidence that antidepressant drugs having the serotonin transporter as their target are effectively used to treat depressive AD patients. The aim of this study was to investigate the role of serotonin in depression, searching for association of two serotoninergic polymorphisms (T102C of serotonin receptor 5-HT2A and serotonin transporter linked polymorphic region -5-HTTLPR- of SLC6A4 gene) with depressive symptoms and considering their possible interactions with Apolipoprotein E (ApoE) and between themselves, in a sample of 208 sporadic AD patients and 116 normal controls from Italy. 5-HTTLPR and T102C are not associated with AD when separately analysed. However, we found out an interaction between the two polymorphisms in L/L and C/C genotype carriers increasing the risk for the disease (p=0.015, OR=8.048; 95% CI: 1.497-43.262). No association of the polymorphisms was detected with depression linked to AD. No interaction between 5-HTTLPR and T102C was detected in depressive AD subjects, even after stratification according to the presence of ApoE4 allele. These results suggest that the serotoninergic system may be not involved in the pathogenesis of depressive symptoms in AD patients, and it may be involved in other aspects of disease pathophysiology like cognitive symptoms and psychosis.

Original languageEnglish
Pages (from-to)371-378
Number of pages8
JournalJournal of Alzheimer's Disease
Volume10
Issue number4
Publication statusPublished - 2006

Keywords

  • 5-HTTLPR
  • Depression
  • Polymorphisms
  • Serotoninergic system
  • T102C

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology

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