No evidence for association and linkage disequilibrium between dyslexia and markers of four dopamine-related genes

C. Marino, R. Giorda, L. Vanzin, M. Molteni, M. L. Lorusso, M. Nobile, C. Baschirotto, M. Alda, M. Battaglia

Research output: Contribution to journalArticle

Abstract

Dopamine genes are candidate genes for dyslexia in the light of the well-known comorbidity between dyslexia and ADHD. Within-family association and linkage disequilibrium were tested between four genetic markers at DRD4, DRD3, DRD2, and DAT loci, and dyslexia, in a sample of 130 Italian dyslexic children, 16.9% of whom had comorbid ADHD. No evidence of either association or linkage disequilibrium was found, neither in the total sample nor in the comorbid subgroup. Negative results do not support a common genetic basis between these two disorders for these markers.

Original languageEnglish
Pages (from-to)198-202
Number of pages5
JournalEuropean Child and Adolescent Psychiatry
Volume12
Issue number4
DOIs
Publication statusPublished - 2003

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Keywords

  • Dopamine receptors
  • Dyslexia
  • Genetics
  • TDT

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Developmental and Educational Psychology

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