No evidence for SEL1L as a candidate gene for IDDM11-conferred susceptibility

Flemming Pociot, Zenia M. Larsen, Patrizia Zavattari, Elisabetta Deidda, Jørn Nerup, Monica Cattaneo, Raffaella Chiaramonte, Paola Comi, Marta Sabbadini, Massimo Zollo, Ida Biunno, Francesco Cucca

Research output: Contribution to journalArticle

Abstract

Background. The SEL1L gene is located on human chromosome 14q24.3-31 close to D14S67 which has been previously proposed to be a type 1 diabetes mellitus locus (IDDM11). Sel-1 is a negative regulator of the Notch signalling pathway and SEL1L is selectively expressed in adult pancreas and islets of Langerhans. This suggests that SEL1L may be a candidate gene for IDDM11. Methods. We have analysed two newly identified CA-repeat polymorphisms within the genomic sequence of the SEL1L locus for association with type 1 diabetes mellitus (T1DM) in 152 Danish T1DM-affected sib-pair families and in 240 Sardinian families (229 simplex and 11 sib-pair families). Results. No evidence for association of the two SEL1L markers with T1DM was observed in either the Danish or the Sardinian families. We have also used allelic sharing methods to analyse linkage with T1DM in the IDDM11 region using the same markers and the Danish collection of affected sib-pair families. No evidence of linkage was observed (Zmax = 0.86). Conclusion. Although several lines of evidence suggest that SEL1L might be a candidate for IDDM11-conferred susceptibility to T1DM the present study does not support this hypothesis.

Original languageEnglish
Pages (from-to)292-295
Number of pages4
JournalDiabetes/Metabolism Research and Reviews
Volume17
Issue number4
DOIs
Publication statusPublished - 2001

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Keywords

  • Candidate gene
  • Genetics
  • IDDM11
  • Pancreas development
  • Type 1 diabetes

ASJC Scopus subject areas

  • Endocrinology
  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Pociot, F., Larsen, Z. M., Zavattari, P., Deidda, E., Nerup, J., Cattaneo, M., Chiaramonte, R., Comi, P., Sabbadini, M., Zollo, M., Biunno, I., & Cucca, F. (2001). No evidence for SEL1L as a candidate gene for IDDM11-conferred susceptibility. Diabetes/Metabolism Research and Reviews, 17(4), 292-295. https://doi.org/10.1002/dmrr.201