No evidence of a higher risk of progression to AIDS in patients with HIV-1-related severe thrombocytopenia

Massimo Galli, Massimo Musicco, Cristina Gervasoni, Anna Lisa Ridolfo, Fosca Niero, Stefano Rusconi, Agostino Riva, Luca Voltolin, Angelica Lupo, Gian Franco Lovicu, Davide Radice, Mauro Moroni

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Abstract

The prognostic role of platelet (PLT) counts was evaluated in a cohort of 1,533 HIV-1-infected subjects followed for a median of 21 months. Thrombocytopenia (TCP), defined as a PLT count ≤100 x 10 9/L was present at enrollment in 11.2% of cases, with counts ≤50 x 10 9/L (severe TCP) in 5.3%. With the subjects with normal PLT counts (PLT >150 x 10 9/L) as the reference group, the relative risk of developing acquired immunodeficiency syndrome (AIDS) was 0.8 [95% confidence interval (CI) 0.5-1.3, p = 0.4] for subjects with severe TCP, 2.1 (95% CI 1.4-3.1, p = 0.002) for those with PLT counts ranging from 51 to 100 x 10 9/L (moderate TCP), and 1.6 (95% CI 1.2-2.1, p = 0.0004) for those with borderline PLT values (PLT ranging from 101 to 150 x 10 9/L). Most of the risk increase associated with moderate TCP and borderline PLT values was explained by a higher prevalence of subjects with an older age and lower CD4 + cell counts. However, at multivariable analysis considering age, sex, risk group, and zidovudine (ZDV) treatment, the risk for subjects with severe TCP remained significantly lower than that for subjects with moderate TCP and borderline values. These results suggest the existence of different types of HIV-1-associated TCP and also suggest that severe TCP (which often arises in the early phases of infection) is not related to disease progression.

Original languageEnglish
Pages (from-to)268-275
Number of pages8
JournalJournal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Volume12
Issue number3
Publication statusPublished - 1996

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Thrombocytopenia
HIV-1
Acquired Immunodeficiency Syndrome
Platelet Count
Blood Platelets
Confidence Intervals
Zidovudine
CD4 Lymphocyte Count
Disease Progression
Infection

Keywords

  • HIV-1
  • Progression to AIDS
  • Thrombocytopenia

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Virology

Cite this

Galli, M., Musicco, M., Gervasoni, C., Ridolfo, A. L., Niero, F., Rusconi, S., ... Moroni, M. (1996). No evidence of a higher risk of progression to AIDS in patients with HIV-1-related severe thrombocytopenia. Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, 12(3), 268-275.

No evidence of a higher risk of progression to AIDS in patients with HIV-1-related severe thrombocytopenia. / Galli, Massimo; Musicco, Massimo; Gervasoni, Cristina; Ridolfo, Anna Lisa; Niero, Fosca; Rusconi, Stefano; Riva, Agostino; Voltolin, Luca; Lupo, Angelica; Lovicu, Gian Franco; Radice, Davide; Moroni, Mauro.

In: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, Vol. 12, No. 3, 1996, p. 268-275.

Research output: Contribution to journalArticle

Galli, M, Musicco, M, Gervasoni, C, Ridolfo, AL, Niero, F, Rusconi, S, Riva, A, Voltolin, L, Lupo, A, Lovicu, GF, Radice, D & Moroni, M 1996, 'No evidence of a higher risk of progression to AIDS in patients with HIV-1-related severe thrombocytopenia', Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, vol. 12, no. 3, pp. 268-275.
Galli, Massimo ; Musicco, Massimo ; Gervasoni, Cristina ; Ridolfo, Anna Lisa ; Niero, Fosca ; Rusconi, Stefano ; Riva, Agostino ; Voltolin, Luca ; Lupo, Angelica ; Lovicu, Gian Franco ; Radice, Davide ; Moroni, Mauro. / No evidence of a higher risk of progression to AIDS in patients with HIV-1-related severe thrombocytopenia. In: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology. 1996 ; Vol. 12, No. 3. pp. 268-275.
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abstract = "The prognostic role of platelet (PLT) counts was evaluated in a cohort of 1,533 HIV-1-infected subjects followed for a median of 21 months. Thrombocytopenia (TCP), defined as a PLT count ≤100 x 10 9/L was present at enrollment in 11.2{\%} of cases, with counts ≤50 x 10 9/L (severe TCP) in 5.3{\%}. With the subjects with normal PLT counts (PLT >150 x 10 9/L) as the reference group, the relative risk of developing acquired immunodeficiency syndrome (AIDS) was 0.8 [95{\%} confidence interval (CI) 0.5-1.3, p = 0.4] for subjects with severe TCP, 2.1 (95{\%} CI 1.4-3.1, p = 0.002) for those with PLT counts ranging from 51 to 100 x 10 9/L (moderate TCP), and 1.6 (95{\%} CI 1.2-2.1, p = 0.0004) for those with borderline PLT values (PLT ranging from 101 to 150 x 10 9/L). Most of the risk increase associated with moderate TCP and borderline PLT values was explained by a higher prevalence of subjects with an older age and lower CD4 + cell counts. However, at multivariable analysis considering age, sex, risk group, and zidovudine (ZDV) treatment, the risk for subjects with severe TCP remained significantly lower than that for subjects with moderate TCP and borderline values. These results suggest the existence of different types of HIV-1-associated TCP and also suggest that severe TCP (which often arises in the early phases of infection) is not related to disease progression.",
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AU - Niero, Fosca

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AU - Riva, Agostino

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AU - Lupo, Angelica

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AU - Radice, Davide

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