No evidence of fetal DNA persistence in maternal plasma after pregnancy

Maddalena Smid, Silvia Galbiati, Antonia Vassallo, Dania Gambini, Augusto Ferrari, Elsa Viora, Marco Pagliano, Gabriella Restagno, Maurizio Ferrari, Laura Cremonesi

Research output: Contribution to journalArticlepeer-review

Abstract

Short- and long-term persistence of fetal DNA in maternal plasma has been investigated. Short-term persistence at very low concentration was detected in 47 out of 105 women within two days after delivery. Twelve out of 13 samples re-tested within three days scored negative. No long-term persistence was detected in 172 women who had previous sons or abortions. Molecular micro-chimerism due to circulating fetal DNA persisting from previous pregnancies should not hamper non-invasive plasma-based prenatal testing.

Original languageEnglish
Pages (from-to)617-618
Number of pages2
JournalHuman Genetics
Volume112
Issue number5-6
Publication statusPublished - May 2003

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

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