No evidence of fetal DNA persistence in maternal plasma after pregnancy

Maddalena Smid; Silvia Galbiati; Antonia Vassallo; Dania Gambini; Augusto Ferrari; Elsa Viora; Marco Pagliano; Gabriella Restagno; Maurizio Ferrari; Laura Cremonesi

No evidence of fetal DNA persistence in maternal plasma after pregnancy

Maddalena Smid, Silvia Galbiati, Antonia Vassallo, Dania Gambini, Augusto Ferrari, Elsa Viora, Marco Pagliano, Gabriella Restagno, Maurizio Ferrari, Laura Cremonesi

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

Short- and long-term persistence of fetal DNA in maternal plasma has been investigated. Short-term persistence at very low concentration was detected in 47 out of 105 women within two days after delivery. Twelve out of 13 samples re-tested within three days scored negative. No long-term persistence was detected in 172 women who had previous sons or abortions. Molecular micro-chimerism due to circulating fetal DNA persisting from previous pregnancies should not hamper non-invasive plasma-based prenatal testing.

Original language	English
Pages (from-to)	617-618
Number of pages	2
Journal	Human Genetics
Volume	112
Issue number	5-6
Publication status	Published - May 2003

ASJC Scopus subject areas

Genetics(clinical)
Genetics

Fingerprint Dive into the research topics of 'No evidence of fetal DNA persistence in maternal plasma after pregnancy'. Together they form a unique fingerprint.

Cite this

No evidence of fetal DNA persistence in maternal plasma after pregnancy. / Smid, Maddalena; Galbiati, Silvia; Vassallo, Antonia; Gambini, Dania; Ferrari, Augusto; Viora, Elsa; Pagliano, Marco; Restagno, Gabriella; Ferrari, Maurizio; Cremonesi, Laura.

In: Human Genetics, Vol. 112, No. 5-6, 05.2003, p. 617-618.

Research output: Contribution to journal › Article › peer-review

@article{19f717dd6f82443f88e6933c6b385ce7,

title = "No evidence of fetal DNA persistence in maternal plasma after pregnancy",

abstract = "Short- and long-term persistence of fetal DNA in maternal plasma has been investigated. Short-term persistence at very low concentration was detected in 47 out of 105 women within two days after delivery. Twelve out of 13 samples re-tested within three days scored negative. No long-term persistence was detected in 172 women who had previous sons or abortions. Molecular micro-chimerism due to circulating fetal DNA persisting from previous pregnancies should not hamper non-invasive plasma-based prenatal testing.",

author = "Maddalena Smid and Silvia Galbiati and Antonia Vassallo and Dania Gambini and Augusto Ferrari and Elsa Viora and Marco Pagliano and Gabriella Restagno and Maurizio Ferrari and Laura Cremonesi",

year = "2003",

month = may,

language = "English",

volume = "112",

pages = "617--618",

journal = "Human Genetics",

issn = "0340-6717",

publisher = "Springer Verlag",

number = "5-6",

}

TY - JOUR

T1 - No evidence of fetal DNA persistence in maternal plasma after pregnancy

AU - Smid, Maddalena

AU - Galbiati, Silvia

AU - Vassallo, Antonia

AU - Gambini, Dania

AU - Ferrari, Augusto

AU - Viora, Elsa

AU - Pagliano, Marco

AU - Restagno, Gabriella

AU - Ferrari, Maurizio

AU - Cremonesi, Laura

PY - 2003/5

Y1 - 2003/5

N2 - Short- and long-term persistence of fetal DNA in maternal plasma has been investigated. Short-term persistence at very low concentration was detected in 47 out of 105 women within two days after delivery. Twelve out of 13 samples re-tested within three days scored negative. No long-term persistence was detected in 172 women who had previous sons or abortions. Molecular micro-chimerism due to circulating fetal DNA persisting from previous pregnancies should not hamper non-invasive plasma-based prenatal testing.

AB - Short- and long-term persistence of fetal DNA in maternal plasma has been investigated. Short-term persistence at very low concentration was detected in 47 out of 105 women within two days after delivery. Twelve out of 13 samples re-tested within three days scored negative. No long-term persistence was detected in 172 women who had previous sons or abortions. Molecular micro-chimerism due to circulating fetal DNA persisting from previous pregnancies should not hamper non-invasive plasma-based prenatal testing.

UR - http://www.scopus.com/inward/record.url?scp=0038620220&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0038620220&partnerID=8YFLogxK

M3 - Article

C2 - 12607116

AN - SCOPUS:0038620220

VL - 112

SP - 617

EP - 618

JO - Human Genetics

JF - Human Genetics

SN - 0340-6717

IS - 5-6

ER -

No evidence of fetal DNA persistence in maternal plasma after pregnancy

Abstract

ASJC Scopus subject areas

Other files and links

Cite this