No evidence of Polyomavirus and EBV infections in Italian patients with mixed cryoglobulinemia infected chronically with HCV

Manola Comar, Nunzia Zanotta, Rossella Del Savio, Fulvia Vascotto, Nadia Calabrese, Francesca Zorat, Gabriele Pozzato

Research output: Contribution to journalArticle


Mixed cryoglobulinemia is a lymphoproliferative disorder associated with hepatitis C virus (HCV). In patients chronically affected by HCV the prevalence of mixed cryoglobulinemia is variable ranging from 0% to 56%. To verify whether polyomaviruses (PyV) play a role in this disorder a total of 222 blood samples from 63 HCV chronic patients, 43 with mixed cryoglobulinemia, 59 chronic lymphocytic leukemia, 50 polytransfused patients, and 50 blood donors were evaluated for Merkel (MCPyV), BKV, JCV, and SV40. EBV was additionally included in the analysis since association with this disorder has been reported. Mixed cryoglobulinemia patients infected chronically with HCV resulted negative for both PyV and EBV. MCPyV was found in 1 subject with Merkel Cell Carcinoma, in 10% of polytransfused and in 10% of blood donors while EBV was detected in 22% of polytransfused, 10% of B-cell lymphatic leukemia patients and 4% of blood donors (P

Original languageEnglish
Pages (from-to)666-671
Number of pages6
JournalJournal of Medical Virology
Issue number4
Publication statusPublished - Apr 2014



  • EBV
  • Hepatitis C virus
  • Mixed cryoglobulinemia
  • Polyomavirus

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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