No gradient exists between lumbar and ventricular cerebrospinal fluid β-endorphin

F. Facchinetti, F. Petraglia, S. Cicero, G. Nappi, M. Valentini, A. R. Genazzani

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

In 8 patients, β-lipotropin (β-LPH), β-endorphin (β-EP), ACTH, protein and chloride concentrations were measured in cerebrospinal fluid (CSF) samples obtained simultaneously from the lumbar space and lateral ventricle. Albumin and IgG levels were significantly higher in lumbar than in ventricular CSF samples while no craniocaudal gradient was observed for neuropeptide concentrations. The importance of molecular weight in determining such a regional distribution is supported also by the similar lumbar and ventricular levels of chlorides. These data would validate the CSF approach through lumbar puncture as a tool for exploring neuropeptides in the central nervous system.

Original languageEnglish
Pages (from-to)349-352
Number of pages4
JournalNeuroscience Letters
Volume77
Issue number3
DOIs
Publication statusPublished - Jun 26 1987

Fingerprint

Endorphins
Cerebrospinal Fluid
Neuropeptides
Chlorides
beta-Lipotropin
Spinal Puncture
Lateral Ventricles
Adrenocorticotropic Hormone
Albumins
Central Nervous System
Immunoglobulin G
Molecular Weight
Proteins

Keywords

  • Adrenocorticotropic hormone
  • Gradient
  • Lumbar cerebrospinal fluid
  • Man
  • Ventricular cerebrospinal fluid
  • β-Endorphin
  • β-Lipotropin

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Facchinetti, F., Petraglia, F., Cicero, S., Nappi, G., Valentini, M., & Genazzani, A. R. (1987). No gradient exists between lumbar and ventricular cerebrospinal fluid β-endorphin. Neuroscience Letters, 77(3), 349-352. https://doi.org/10.1016/0304-3940(87)90526-X

No gradient exists between lumbar and ventricular cerebrospinal fluid β-endorphin. / Facchinetti, F.; Petraglia, F.; Cicero, S.; Nappi, G.; Valentini, M.; Genazzani, A. R.

In: Neuroscience Letters, Vol. 77, No. 3, 26.06.1987, p. 349-352.

Research output: Contribution to journalArticle

Facchinetti, F, Petraglia, F, Cicero, S, Nappi, G, Valentini, M & Genazzani, AR 1987, 'No gradient exists between lumbar and ventricular cerebrospinal fluid β-endorphin', Neuroscience Letters, vol. 77, no. 3, pp. 349-352. https://doi.org/10.1016/0304-3940(87)90526-X
Facchinetti F, Petraglia F, Cicero S, Nappi G, Valentini M, Genazzani AR. No gradient exists between lumbar and ventricular cerebrospinal fluid β-endorphin. Neuroscience Letters. 1987 Jun 26;77(3):349-352. https://doi.org/10.1016/0304-3940(87)90526-X
Facchinetti, F. ; Petraglia, F. ; Cicero, S. ; Nappi, G. ; Valentini, M. ; Genazzani, A. R. / No gradient exists between lumbar and ventricular cerebrospinal fluid β-endorphin. In: Neuroscience Letters. 1987 ; Vol. 77, No. 3. pp. 349-352.
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