No impact of interleukin-28B polymorphisms on spontaneous or drug-induced hepatitis delta virus clearance

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Abstract

Background: rs12979860 and rs8099917 interleukin-28B polymorphisms are associated with spontaneous or interferon-alpha induced hepatitis C clearance, "CC" and "TT" genotypes (respectively) being the most favourable. There are no data on the influence of interleukin-28B polymorphisms on hepatitis delta clearance in hepatitis B/D co-infected patients. Aims: The present study explores the potential influence of both rs12979860 and rs8099917 polymorphisms on delta infection outcome. Methods: Retrospective-longitudinal study on 55 European patients observed for at least 4 years, selected from a cohort of 439 subjects positive for hepatitis delta antibodies and hepatitis B core antibodies.The rate of spontaneous and interferon induced delta-RNA clearance was compared in interleukin-28B rs12979860 "CC" vs "non CC", and in rs8099917 "TT" vs "non TT" genotypes. Results: Prevalence of rs12979860. C allele was 60%, consistent with the reported prevalence in Italy (67%, p=. 0.128). No significant differences in spontaneous clearance rate were observed between rs12979860 "CC" and "non CC" genotypes (13.3% vs 7.5%, respectively, p=. 0.60), and between rs8099917 "TT" and "non-TT" genotypes (11.1 vs 7.1%, respectively, p=. 0.67). No differences were observed for interferon-induced delta-RNA clearance either. Conclusions: Our data suggest that interleukin-28B polymorphisms might not influence hepatitis delta clearance rate in either natural history or interferon-alpha response.

Original languageEnglish
Pages (from-to)348-352
Number of pages5
JournalDigestive and Liver Disease
Volume46
Issue number4
DOIs
Publication statusPublished - 2014

Keywords

  • HDV infection
  • IFN treatment
  • IL28B
  • Viral clearance

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

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