No Ink on Ductal Carcinoma In Situ

A Single Centre Experience

Piero Fregatti, Marco Gipponi, Francesca Depaoli, Federica Murelli, Marina Guenzi, Elisabetta Bonzano, Marcello Ceppi, Daniele Friedman

Research output: Contribution to journalArticle

Abstract

BACKGROUND/AIM: A retrospective analysis of 388 patients with pure ductal carcinoma in situ (DCIS) was performed in order to test the correlation of clearance margin of resection and other host-, tumor- and treatment-related factors with ipsilateral breast tumor recurrence (IBTR). MATERIALS AND METHODS: The pathological analysis was performed according to a standardized protocol: positive margins had DCIS at the inked margin; close margins had tumor between 0.1 to 0.9 mm, or 1 to 1.9 mm, and negative margins were ≥2 mm. RESULTS: At a median follow-up of 90 months there were 26 IBTR (10 invasive and 16 DCIS). Both in univariate and multivariate analysis a significant difference was observed in IBTR by comparing positive versus close/negative margins of excision (p=0.05) and the number of re-operations (p=0.000). Moreover, the actuarial IBTR rates were significantly different in patients with a positive compared to close/negative margins (log-rank test, p=0.042) while the stratification by the margin width (0.1-0.9 mm; 1.0-1.9 mm; ≥2 mm) was not significant (log-rank test, p=0.243). CONCLUSION: The policy of "no ink on the tumor" can be translated from invasive to DCIS, because the actuarial IBTR rates were significantly different only in patients with a positive, compared to close/negative margins.

Original languageEnglish
Pages (from-to)459-466
Number of pages8
JournalAnticancer Research
Volume39
Issue number1
DOIs
Publication statusPublished - Jan 1 2019

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Ink
Carcinoma, Intraductal, Noninfiltrating
Breast Neoplasms
Recurrence
Neoplasms
Multivariate Analysis

Keywords

  • Breast cancer
  • DCIS
  • margin of excision

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

No Ink on Ductal Carcinoma In Situ : A Single Centre Experience. / Fregatti, Piero; Gipponi, Marco; Depaoli, Francesca; Murelli, Federica; Guenzi, Marina; Bonzano, Elisabetta; Ceppi, Marcello; Friedman, Daniele.

In: Anticancer Research, Vol. 39, No. 1, 01.01.2019, p. 459-466.

Research output: Contribution to journalArticle

Fregatti P, Gipponi M, Depaoli F, Murelli F, Guenzi M, Bonzano E et al. No Ink on Ductal Carcinoma In Situ: A Single Centre Experience. Anticancer Research. 2019 Jan 1;39(1):459-466. https://doi.org/10.21873/anticanres.13134
Fregatti, Piero ; Gipponi, Marco ; Depaoli, Francesca ; Murelli, Federica ; Guenzi, Marina ; Bonzano, Elisabetta ; Ceppi, Marcello ; Friedman, Daniele. / No Ink on Ductal Carcinoma In Situ : A Single Centre Experience. In: Anticancer Research. 2019 ; Vol. 39, No. 1. pp. 459-466.
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