No interaction between serotonin transporter gene and dopamine receptor D4 gene in symptomatology of major psychoses

Alessandro Serretti, Cristina Cusin, Enrico Lattuada, Roberta Lilli, Cristina Lorenzi, Daniela Di Bella, Marco Catalano, Enrico Smeraldi

Research output: Contribution to journalArticlepeer-review


Previously, we reported an association of the dopamine receptor D4 (DRD4) gene with delusional symptomatology of major psychoses. However, DRD4 variants accounted for only 2% of the phenotypic variance, indicating that contributions from other genes were probable. The serotonin transporter gene is a primary candidate in major psychoses, and a functional polymorphism in the upstream regulatory region of the serotonin transporter gene (5-HTTLPR) has recently been reported to be associated with a number of psychopathological conditions. In the present study we investigated the original cohort of subjects to evaluate the 5-HTTLPR possible influence on the psychopathology of major psychoses in interaction with DRD4. Four hundred and sixty-one inpatients affected by major psychoses were assessed by the Operational Criteria Checklist for Psychotic Illness (OPCRIT) and were also typed for the 5-HTTLPR and DRD4 variants using polymerase chain reaction techniques. Mania, depression, delusion, and disorganization were the four symptomatologic factors used as phenotype definition. 5-HTTLPR variants did not significantly influence the previously reported association of DRD4 with delusional symptoms. No interaction was observed on the other symptom factors. The serotonin transporter gene does not, therefore, interact with DRD4 in determining the symptomatology of major psychoses.

Original languageEnglish
Pages (from-to)481-485
Number of pages5
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Issue number5
Publication statusPublished - Oct 15 1999


  • Bipolar disorder
  • Depressive disorder
  • Dopamine receptors
  • Epistasis genetic
  • Paranoid disorder
  • Phenotype
  • Schizophrenia
  • Serotonin

ASJC Scopus subject areas

  • Genetics(clinical)
  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)


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