TY - JOUR
T1 - No metagenomic evidence of tumorigenic viruses in cancers from a selected cohort of immunosuppressed subjects
AU - Passaro, Nunzia
AU - Casagrande, Andrea
AU - Chiara, Matteo
AU - Fosso, Bruno
AU - Manzari, Caterina
AU - D'Erchia, Anna Maria
AU - Iesari, Samuele
AU - Pisani, Francesco
AU - Famulari, Antonio
AU - Tulissi, Patrizia
AU - Mastrosimone, Stefania
AU - Maresca, Maria Cristina
AU - Mercante, Giuseppe
AU - Spriano, Giuseppe
AU - Corrado, Giacomo
AU - Vizza, Enrico
AU - Garbuglia, Anna Rosa
AU - Capobianchi, Maria Rosaria
AU - Mottini, Carla
AU - Cenci, Alessandra
AU - Tartaglia, Marco
AU - Costa, Alessandro Nanni
AU - Pesole, Graziano
AU - Crescenzi, Marco
N1 - undefined; J2: Sci Rep
M1 - Journal Article
PY - 2019
Y1 - 2019
N2 - The possible existence of yet undiscovered human tumorigenic viruses is still under scrutiny. The development of large-scale sequencing technologies, coupled with bioinformatics techniques for the characterization of metagenomic sequences, have provided an invaluable tool for the detection of unknown, infectious, tumorigenic agents, as demonstrated by several recent studies. However, discoveries of novel viruses possibly associated with tumorigenesis are scarce at best. Here, we apply a rigorous bioinformatics workflow to investigate in depth tumor metagenomes from a small but carefully selected cohort of immunosuppressed patients. While a variegated bacterial microbiome was associated with each tumor, no evidence of the presence of putative oncoviruses was found. These results are consistent with the major findings of several recent papers and suggest that new human tumorigenic viruses are not common even in immunosuppressed populations.
AB - The possible existence of yet undiscovered human tumorigenic viruses is still under scrutiny. The development of large-scale sequencing technologies, coupled with bioinformatics techniques for the characterization of metagenomic sequences, have provided an invaluable tool for the detection of unknown, infectious, tumorigenic agents, as demonstrated by several recent studies. However, discoveries of novel viruses possibly associated with tumorigenesis are scarce at best. Here, we apply a rigorous bioinformatics workflow to investigate in depth tumor metagenomes from a small but carefully selected cohort of immunosuppressed patients. While a variegated bacterial microbiome was associated with each tumor, no evidence of the presence of putative oncoviruses was found. These results are consistent with the major findings of several recent papers and suggest that new human tumorigenic viruses are not common even in immunosuppressed populations.
U2 - 10.1038/s41598-019-56240-1
DO - 10.1038/s41598-019-56240-1
M3 - Articolo
VL - 9
SP - 19815
JO - Sci. Rep.
JF - Sci. Rep.
SN - 2045-2322
IS - 1
ER -