No metagenomic evidence of tumorigenic viruses in cancers from a selected cohort of immunosuppressed subjects

Nunzia Passaro, Andrea Casagrande, Matteo Chiara, Bruno Fosso, Caterina Manzari, Anna Maria D'Erchia, Samuele Iesari, Francesco Pisani, Antonio Famulari, Patrizia Tulissi, Stefania Mastrosimone, Maria Cristina Maresca, Giuseppe Mercante, Giuseppe Spriano, Giacomo Corrado, Enrico Vizza, Anna Rosa Garbuglia, Maria Rosaria Capobianchi, Carla Mottini, Alessandra CenciMarco Tartaglia, Alessandro Nanni Costa, Graziano Pesole, Marco Crescenzi

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The possible existence of yet undiscovered human tumorigenic viruses is still under scrutiny. The development of large-scale sequencing technologies, coupled with bioinformatics techniques for the characterization of metagenomic sequences, have provided an invaluable tool for the detection of unknown, infectious, tumorigenic agents, as demonstrated by several recent studies. However, discoveries of novel viruses possibly associated with tumorigenesis are scarce at best. Here, we apply a rigorous bioinformatics workflow to investigate in depth tumor metagenomes from a small but carefully selected cohort of immunosuppressed patients. While a variegated bacterial microbiome was associated with each tumor, no evidence of the presence of putative oncoviruses was found. These results are consistent with the major findings of several recent papers and suggest that new human tumorigenic viruses are not common even in immunosuppressed populations.
Original languageUndefined/Unknown
JournalSci. Rep.
Publication statusPublished - Dec 24 2019

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