TY - JOUR
T1 - NO points to epigenetics in vascular development
AU - Illi, Barbara
AU - Colussi, Claudia
AU - Rosati, Jessica
AU - Spallotta, Francesco
AU - Nanni, Simona
AU - Farsetti, Antonella
AU - Capogrossi, Maurizio C.
AU - Gaetano, Carlo
PY - 2011/6/1
Y1 - 2011/6/1
N2 - Our understanding of epigenetic mechanisms important for embryonic vascular development and cardiovascular differentiation is still in its infancy. Although molecular analyses, including massive genome sequencing and/or in vitro/in vivo targeting of specific gene sets, has led to the identification of multiple factors involved in stemness maintenance or in the early processes of embryonic layers specification, very little is known about the epigenetic commitment to cardiovascular lineages. The object of this review will be to outline the state of the art in this field and trace the perspective therapeutic consequences of studies aimed at elucidating fundamental epigenetic networks. Special attention will be paid to the emerging role of nitric oxide in this field.
AB - Our understanding of epigenetic mechanisms important for embryonic vascular development and cardiovascular differentiation is still in its infancy. Although molecular analyses, including massive genome sequencing and/or in vitro/in vivo targeting of specific gene sets, has led to the identification of multiple factors involved in stemness maintenance or in the early processes of embryonic layers specification, very little is known about the epigenetic commitment to cardiovascular lineages. The object of this review will be to outline the state of the art in this field and trace the perspective therapeutic consequences of studies aimed at elucidating fundamental epigenetic networks. Special attention will be paid to the emerging role of nitric oxide in this field.
KW - Epigenetics
KW - Nitric oxide
KW - Vascular development
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U2 - 10.1093/cvr/cvr056
DO - 10.1093/cvr/cvr056
M3 - Article
C2 - 21345806
AN - SCOPUS:79957474768
VL - 90
SP - 447
EP - 456
JO - Cardiovascular Research
JF - Cardiovascular Research
SN - 0008-6363
IS - 3
ER -