NO points to epigenetics in vascular development

Barbara Illi, Claudia Colussi, Jessica Rosati, Francesco Spallotta, Simona Nanni, Antonella Farsetti, Maurizio C. Capogrossi, Carlo Gaetano

Research output: Contribution to journalArticle

Abstract

Our understanding of epigenetic mechanisms important for embryonic vascular development and cardiovascular differentiation is still in its infancy. Although molecular analyses, including massive genome sequencing and/or in vitro/in vivo targeting of specific gene sets, has led to the identification of multiple factors involved in stemness maintenance or in the early processes of embryonic layers specification, very little is known about the epigenetic commitment to cardiovascular lineages. The object of this review will be to outline the state of the art in this field and trace the perspective therapeutic consequences of studies aimed at elucidating fundamental epigenetic networks. Special attention will be paid to the emerging role of nitric oxide in this field.

Original languageEnglish
Pages (from-to)447-456
Number of pages10
JournalCardiovascular Research
Volume90
Issue number3
DOIs
Publication statusPublished - Jun 1 2011

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Keywords

  • Epigenetics
  • Nitric oxide
  • Vascular development

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)
  • Physiology

Cite this

Illi, B., Colussi, C., Rosati, J., Spallotta, F., Nanni, S., Farsetti, A., Capogrossi, M. C., & Gaetano, C. (2011). NO points to epigenetics in vascular development. Cardiovascular Research, 90(3), 447-456. https://doi.org/10.1093/cvr/cvr056