No pol mutation is associated independently with the lack of immune recovery in patients infected with HIV and failing antiretroviral therapy

Nicola Gianotti, Laura Galli, Maurizio Zazzi, Valeria Ghisetti, Stefano Bonora, Valeria Micheli, Paola Meraviglia, Paola Corsi, Bianca Bruzzone, Stefano Menzo, Simona Di Giambenedetto, Andrea De Luca, Gaetano Filice, Giovanni Penco, Antonella Castagna

Research output: Contribution to journalArticlepeer-review

Abstract

An investigation was undertaken to determine whether specific pol mutations hinder long-term immune recovery regardless of virological response. In total, 826 patients with >50 HIV RNA copies/ml, who underwent genotypic resistance testing between 1 January 2000 and 31 December 2003 after >3 years of antiretroviral treatment, and were followed up for >3 years after genotypic resistance testing, were analyzed retrospectively. The outcome of the study was the lack of immune recovery after >3 years of follow-up, defined as a slope by linear regression 50 copies/ml divided by the number of HIV RNA measurements during follow-up. Logistic regression was used for univariable and multivariable analysis. Median (Q1, Q3) values at baseline were the following: age 40 (37, 45) years, years on antiretroviral therapy 4.45 (3.65, 5.47), HIV RNA 3.91 (3.39, 4.53) log 10 copies/ml, CD4+ T-cell 358 (211, 524)/μl. After 3.13 years of follow-up, 375 patients (45.4%) showed a lack of immune recovery. The risk of lack of immune recovery increased independently with increasing baseline CD4+ counts (OR=1.104 per 50-cell increase, 95% CI=1.069-1.142, P

Original languageEnglish
Pages (from-to)391-398
Number of pages8
JournalJournal of Medical Virology
Volume83
Issue number3
DOIs
Publication statusPublished - Mar 2011

Keywords

  • CD4+ T-lymphocytes
  • Drug resistance
  • Resistance to non-nucleoside reverse transcriptase inhibitors
  • Resistance to nucleoside reverse transcriptase inhibitors
  • Resistance to protease inhibitors

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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