No protective effect of acyclovir on HIV disease progression in a cohort of HSV-2-HIV-infected individuals

Barbara Suligoi, Maria Dorrucci, Antonio Volpi, Massimo Andreoni, Giovanni Rezza, Patrizio Pezzotti, Alessandro Sinicco, Roberto Zerboni, Gioacchino Angarano, Adriano Lazzarin, Fernando Aiuti, Mauro Zaccarelli, Bernardino Salassa, Francesco Castelli, Francesco Alberici, Giovanni Mazzarello, Mauro Barbanera, Vincenzo Colangeli, Luigi Ortona, Raffaele PristeràMaria A. Ursitti, Umberto Tirelli, Massimo Giuliani

Research output: Contribution to journalArticlepeer-review


The efficacy of anti-herpetic drugs in decreasing HIV disease progression has not been clarified. We studied a cohort of 126 HIV-positive individuals with known date of seroconversion who were HSV-2-seropositive to determine if progression to AIDS was influenced by treatment with acyclovir. In the multivariate analysis, being homosexual and low CD4 count were associated with a faster progression to AIDS, whereas treatment with acyclovir showed a 37.0% protective effect compared to those who did not receive it when antiretroviral treatment was not included in the model. When including antiretroviral therapy, the protective effect of acyclovir decreased to 9.0% and that of antiretroviral therapy was 43.0% for monotherapy and 36.0% for double therapy, suggesting that most of the protective effect of acyclovir in the previous model was due to antiretroviral therapy. In conclusion, treatment with acyclovir does not seem to prolong significantly survival to AIDS among HIV-positive individuals who are HSV-2-infected.

Original languageEnglish
Pages (from-to)289-291
Number of pages3
JournalAntiviral Therapy
Issue number4
Publication statusPublished - Dec 2002

ASJC Scopus subject areas

  • Pharmacology


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