No-reflow reversibility: A study based on serial assessment of multiple biomarkers

Giampaolo Niccoli, Francesco Fracassi, Nicola Cosentino, Elena Falcioni, Marco Roberto, Giuseppe De Luca, Antonio Maria Leone, Francesco Burzotta, Italo Porto, Carlo Trani, Anna Severino, Filippo Crea

Research output: Contribution to journalArticle

Abstract

No-reflow after primary percutaneous coronary intervention (pPCI) may be reversible. 40 patients undergoing pPCI were evaluated by assessing either improvement or lack of changes regarding angiographic and electrocardiographic indexes of no-reflow between admission and pre-discharge. Myeloperoxidase (MPO; in nanograms per milliliter), C-reactive protein (CRP; in milligrams per liter), endothelin-1 (ET-1; in nanograms per milliliter), angiopoietin-2 (Ang-2, in picograms per milliliter), and their pre-discharge/basal values variations (Δ) were related to no-reflow evolution. ΔMPO and ΔCRP were greater in patients with sustained no-reflow or lack of ST-segment resolution (STR) as compared with those with reversible no-reflow or lack of STR (p = 0.033, p = 0.04, p <0.001, and p = 0.001, respectively), whereas ΔET-1 was similar in the two groups. ΔAng-2 was greater in patients with sustained no-reflow or lack of STR as compared with those with reversible no-reflow or lack of STR (p = 0.01 and 0.044, respectively). Bigger ΔMPO, ΔCRP (increasing levels), and ΔAng-2 (decreasing levels) are associated with sustained no-reflow, thus they might have a role in no-reflow evolution.

Original languageEnglish
Pages (from-to)798-807
Number of pages10
JournalJournal of Cardiovascular Translational Research
Volume6
Issue number5
DOIs
Publication statusPublished - Oct 2013

    Fingerprint

Keywords

  • Inflammation
  • Neoangiogenesis
  • No-reflow
  • Primary percutaneous coronary intervention
  • ST-elevation myocardial infarction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Genetics
  • Genetics(clinical)
  • Molecular Medicine
  • Pharmaceutical Science

Cite this

Niccoli, G., Fracassi, F., Cosentino, N., Falcioni, E., Roberto, M., De Luca, G., Leone, A. M., Burzotta, F., Porto, I., Trani, C., Severino, A., & Crea, F. (2013). No-reflow reversibility: A study based on serial assessment of multiple biomarkers. Journal of Cardiovascular Translational Research, 6(5), 798-807. https://doi.org/10.1007/s12265-013-9509-5