No risk of maternal EBV infection for childhood leukemia

Rosamaria Tedeschi, Tapio Luostarinen, Alessia Marus, Davit Bzhalava, Helga M. Ögmundsdottir, Joakim Dillner, Paolo De Paoli, Heljä Marja Surcel, Eero Pukkala, Matti Lehtinen, Tuula Lehtinen

Research output: Contribution to journalArticlepeer-review

Abstract

We performed a large nested case-control study within the Finnish and Icelandic maternity cohorts to verify/ falsify the association of maternal EBV infection with an increased risk of acute lymphoblastic leukemia (ALL) in the offspring found in previous studies. All hematologic malignancies diagnosed among children born during 1983 to 2006 in Finland and 1997 to 2005 in Iceland were identified through national cancer registries. For each index mother of a leukemia case, three matched control mothers with cancer-free offspring were identified. First trimester sera from 561 ALL and 144 non-ALL index mothers and from 2,105 control mothers were analyzed for antibodies to EBV viral capsid antigen (IgG and IgM), early antigen (IgG) and ZEBRA protein (IgG). Conditional logistic regression-based estimates of odds ratios and 95% confidence intervals adjusted for birth order and sib-ship size were calculated. Overall, there was no evidence of increased risk of ALL associated to EBV viral capsid antigen IgM (odds ratio, 0.9; 95% confidence interval, 0.5-1.8). The early antigen and ZEBRA antibodies (EBV reactivation markers) were also not associated with risk. The data argue against a role of EBV in ALL.

Original languageEnglish
Pages (from-to)2790-2792
Number of pages3
JournalCancer Epidemiology Biomarkers and Prevention
Volume18
Issue number10
DOIs
Publication statusPublished - Oct 2009

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Fingerprint Dive into the research topics of 'No risk of maternal EBV infection for childhood leukemia'. Together they form a unique fingerprint.

Cite this