No support for premature central nervous system aging in HIV-1 when measured by cerebrospinal fluid phosphorylated tau (p-tau)

JJ Krut, RW Price, H Zetterberg, D Fuchs, L Hagberg, A Yilmaz, P Cinque, S Nilsson, M Gisslén

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The prevalence of neurocognitive deficits are reported to be high in HIV-1 positive patients, even with suppressive antiretroviral treatment, and it has been suggested that HIV can cause accelerated aging of the brain. In this study we measured phosphorylated tau (p-tau) in cerebrospinal fluid (CSF) as a potential marker for premature central nervous system (CNS) aging. P-tau increases with normal aging but is not affected by HIV-associated neurocognitive disorders. Methods: With a cross-sectional retrospective design, p-tau, total tau (t-tau), neopterin and HIV-RNA were measured in CSF together with plasma HIV-RNA and blood CD4+ T-cells of 225 HIV-infected patients
Original languageEnglish
Pages (from-to)599-604
Number of pages6
JournalVirulence
Volume8
Issue number5
DOIs
Publication statusPublished - 2017

Fingerprint Dive into the research topics of 'No support for premature central nervous system aging in HIV-1 when measured by cerebrospinal fluid phosphorylated tau (p-tau)'. Together they form a unique fingerprint.

Cite this