Abstract
Presence of asthma symptoms during the night are a known component of the disease. It is still unclear whether night time symptoms are an expression of increased asthma severity or whether nocturnal asthma is a distinct entity. A number of mechanisms have been hypothesized to explain the phenomenon of nocturnal asthma, including exposure to dust mite allergen, late-phase allergic reactions, effects of posture and sleep stage on airway tone, gastro-esophageal reflex, impaired mucociliary clearance, airway cooling, and changes in circadian rhythms of circulating hormones. Several therapeutic options have been studied over the years. These include chronobiological use of corticosteroids, long acting β-agonists, theophylline derivatives and antileukotriene drugs. Correction of comorbidities such as gastro-esophageal reflux disease or sleep apnea may contribute to symptom control in selected cases. Further studies would be useful to better define the underlying mechanisms of nocturnal asthma and response to therapeutic measures.
| Original language | English |
|---|---|
| Pages (from-to) | 61-71 |
| Number of pages | 11 |
| Journal | Minerva Pneumologica |
| Volume | 48 |
| Issue number | 1 |
| Publication status | Published - Mar 2009 |
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Keywords
- Asthma - dyspnea
- Paroxysmal - dermatophagoides pteronyssinus- sleep apnea syndromes
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
Cite this
Nocturnal asthma. / Blasi, F.; Zanardelli, M.; Castellotti, P.; Tarsia, P.
In: Minerva Pneumologica, Vol. 48, No. 1, 03.2009, p. 61-71.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Nocturnal asthma
AU - Blasi, F.
AU - Zanardelli, M.
AU - Castellotti, P.
AU - Tarsia, P.
PY - 2009/3
Y1 - 2009/3
N2 - Presence of asthma symptoms during the night are a known component of the disease. It is still unclear whether night time symptoms are an expression of increased asthma severity or whether nocturnal asthma is a distinct entity. A number of mechanisms have been hypothesized to explain the phenomenon of nocturnal asthma, including exposure to dust mite allergen, late-phase allergic reactions, effects of posture and sleep stage on airway tone, gastro-esophageal reflex, impaired mucociliary clearance, airway cooling, and changes in circadian rhythms of circulating hormones. Several therapeutic options have been studied over the years. These include chronobiological use of corticosteroids, long acting β-agonists, theophylline derivatives and antileukotriene drugs. Correction of comorbidities such as gastro-esophageal reflux disease or sleep apnea may contribute to symptom control in selected cases. Further studies would be useful to better define the underlying mechanisms of nocturnal asthma and response to therapeutic measures.
AB - Presence of asthma symptoms during the night are a known component of the disease. It is still unclear whether night time symptoms are an expression of increased asthma severity or whether nocturnal asthma is a distinct entity. A number of mechanisms have been hypothesized to explain the phenomenon of nocturnal asthma, including exposure to dust mite allergen, late-phase allergic reactions, effects of posture and sleep stage on airway tone, gastro-esophageal reflex, impaired mucociliary clearance, airway cooling, and changes in circadian rhythms of circulating hormones. Several therapeutic options have been studied over the years. These include chronobiological use of corticosteroids, long acting β-agonists, theophylline derivatives and antileukotriene drugs. Correction of comorbidities such as gastro-esophageal reflux disease or sleep apnea may contribute to symptom control in selected cases. Further studies would be useful to better define the underlying mechanisms of nocturnal asthma and response to therapeutic measures.
KW - Asthma - dyspnea
KW - Paroxysmal - dermatophagoides pteronyssinus- sleep apnea syndromes
UR - http://www.scopus.com/inward/record.url?scp=67649583184&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67649583184&partnerID=8YFLogxK
M3 - Article
VL - 48
SP - 61
EP - 71
JO - Minerva Pneumologica
JF - Minerva Pneumologica
SN - 0026-4954
IS - 1
ER -