Nocturnal hypoglycaemia in ACTH and GH deficient children: Role of continuous glucose monitoring

Paola Cambiaso, Riccardo Schiaffini, Giuseppe Pontrelli, Chiara Carducci, Graziamaria Ubertini, Francesca Crea, Marco Cappa

Research output: Contribution to journalArticle

Abstract

Objectives To evaluate the usefulness of continuous glucose monitoring (CGM) to identify nocturnal hypoglycaemia in children affected by combined ACTH and GH deficiency and to optimize the hydrocortisone replacement therapy in these patients. Study design Eleven patients with ACTH and GH deficiency (five boys and six girls, age 1·6-16·8 years) underwent CGM for 36 h, including two nights. At least two consecutive glucose levels 2/day; P = 0·04). Eight patients presented glucose values less than 3·33 mm during 5% of the total monitoring time. Hydrocortisone dose showed significant positive linear relation with mean glucose level (r = 0·79, P = 0·0035) and inverse relation with time lags of glucose levels under 3·33 mm (r = -0·65, P = 0·03). Conclusions Our study shows that CGM may represent a valuable tool to detect nocturnal asymptomatic hypoglycaemic episodes and optimize the hydrocortisone therapeutic regimen in children with ACTH and GH deficiency.

Original languageEnglish
Pages (from-to)232-237
Number of pages6
JournalClinical Endocrinology
Volume79
Issue number2
DOIs
Publication statusPublished - Aug 2013

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

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