Nocturnal hypoglycaemia in ACTH and GH deficient children

Role of continuous glucose monitoring

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8 Citations (Scopus)

Abstract

Objectives To evaluate the usefulness of continuous glucose monitoring (CGM) to identify nocturnal hypoglycaemia in children affected by combined ACTH and GH deficiency and to optimize the hydrocortisone replacement therapy in these patients. Study design Eleven patients with ACTH and GH deficiency (five boys and six girls, age 1·6-16·8 years) underwent CGM for 36 h, including two nights. At least two consecutive glucose levels 2/day; P = 0·04). Eight patients presented glucose values less than 3·33 mm during 5% of the total monitoring time. Hydrocortisone dose showed significant positive linear relation with mean glucose level (r = 0·79, P = 0·0035) and inverse relation with time lags of glucose levels under 3·33 mm (r = -0·65, P = 0·03). Conclusions Our study shows that CGM may represent a valuable tool to detect nocturnal asymptomatic hypoglycaemic episodes and optimize the hydrocortisone therapeutic regimen in children with ACTH and GH deficiency.

Original languageEnglish
Pages (from-to)232-237
Number of pages6
JournalClinical Endocrinology
Volume79
Issue number2
DOIs
Publication statusPublished - Aug 2013

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Hypoglycemia
Adrenocorticotropic Hormone
Glucose
Hydrocortisone
Hypoglycemic Agents
Therapeutics

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

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title = "Nocturnal hypoglycaemia in ACTH and GH deficient children: Role of continuous glucose monitoring",
abstract = "Objectives To evaluate the usefulness of continuous glucose monitoring (CGM) to identify nocturnal hypoglycaemia in children affected by combined ACTH and GH deficiency and to optimize the hydrocortisone replacement therapy in these patients. Study design Eleven patients with ACTH and GH deficiency (five boys and six girls, age 1·6-16·8 years) underwent CGM for 36 h, including two nights. At least two consecutive glucose levels 2/day; P = 0·04). Eight patients presented glucose values less than 3·33 mm during 5{\%} of the total monitoring time. Hydrocortisone dose showed significant positive linear relation with mean glucose level (r = 0·79, P = 0·0035) and inverse relation with time lags of glucose levels under 3·33 mm (r = -0·65, P = 0·03). Conclusions Our study shows that CGM may represent a valuable tool to detect nocturnal asymptomatic hypoglycaemic episodes and optimize the hydrocortisone therapeutic regimen in children with ACTH and GH deficiency.",
author = "Paola Cambiaso and Riccardo Schiaffini and Giuseppe Pontrelli and Chiara Carducci and Graziamaria Ubertini and Francesca Crea and Marco Cappa",
year = "2013",
month = "8",
doi = "10.1111/cen.12123",
language = "English",
volume = "79",
pages = "232--237",
journal = "Clinical Endocrinology",
issn = "0300-0664",
publisher = "Wiley-Blackwell",
number = "2",

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TY - JOUR

T1 - Nocturnal hypoglycaemia in ACTH and GH deficient children

T2 - Role of continuous glucose monitoring

AU - Cambiaso, Paola

AU - Schiaffini, Riccardo

AU - Pontrelli, Giuseppe

AU - Carducci, Chiara

AU - Ubertini, Graziamaria

AU - Crea, Francesca

AU - Cappa, Marco

PY - 2013/8

Y1 - 2013/8

N2 - Objectives To evaluate the usefulness of continuous glucose monitoring (CGM) to identify nocturnal hypoglycaemia in children affected by combined ACTH and GH deficiency and to optimize the hydrocortisone replacement therapy in these patients. Study design Eleven patients with ACTH and GH deficiency (five boys and six girls, age 1·6-16·8 years) underwent CGM for 36 h, including two nights. At least two consecutive glucose levels 2/day; P = 0·04). Eight patients presented glucose values less than 3·33 mm during 5% of the total monitoring time. Hydrocortisone dose showed significant positive linear relation with mean glucose level (r = 0·79, P = 0·0035) and inverse relation with time lags of glucose levels under 3·33 mm (r = -0·65, P = 0·03). Conclusions Our study shows that CGM may represent a valuable tool to detect nocturnal asymptomatic hypoglycaemic episodes and optimize the hydrocortisone therapeutic regimen in children with ACTH and GH deficiency.

AB - Objectives To evaluate the usefulness of continuous glucose monitoring (CGM) to identify nocturnal hypoglycaemia in children affected by combined ACTH and GH deficiency and to optimize the hydrocortisone replacement therapy in these patients. Study design Eleven patients with ACTH and GH deficiency (five boys and six girls, age 1·6-16·8 years) underwent CGM for 36 h, including two nights. At least two consecutive glucose levels 2/day; P = 0·04). Eight patients presented glucose values less than 3·33 mm during 5% of the total monitoring time. Hydrocortisone dose showed significant positive linear relation with mean glucose level (r = 0·79, P = 0·0035) and inverse relation with time lags of glucose levels under 3·33 mm (r = -0·65, P = 0·03). Conclusions Our study shows that CGM may represent a valuable tool to detect nocturnal asymptomatic hypoglycaemic episodes and optimize the hydrocortisone therapeutic regimen in children with ACTH and GH deficiency.

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U2 - 10.1111/cen.12123

DO - 10.1111/cen.12123

M3 - Article

VL - 79

SP - 232

EP - 237

JO - Clinical Endocrinology

JF - Clinical Endocrinology

SN - 0300-0664

IS - 2

ER -