Nocturnal sleep and oxygen balance in Duchenne muscular dystrophy - A clinicla and polygraphic 2-year follow-up study

Raffaele Manni, Claudio Zucca, Carlo Andrea Galimberti, Alberto ottolini, Isa Cerveri, Claudio Bruschi, Maria Cristina Zoia, Giovanni Lanzi, Amelia Tartara

Research output: Contribution to journalArticlepeer-review

Abstract

A long-term, clinical and polygraphic investigation of nocturnal sleep was performed in nine non-ambulatory Duchenne muscular dystrophy patients (mean age 16.2 years, range 10-20) with normal daytime blood gas tensions. The data show that nocturnal sleep has some adverse influence on oxygen balance in these patients as suggested by the occurrence of arterial oxyhaemoglobin desaturation occurring mainly during REM stages. This adverse effect tended to worsen significantly within a 2-year period in the absence of any sleep-related symptoms. A significant correlation between the degree of oxygen imbalance during sleep and the degree of restrictive thoratic syndrome during wakefulness was shown.

Original languageEnglish
Pages (from-to)255-257
Number of pages3
JournalEuropean Archives of Psychiatry and Clinical Neuroscience
Volume240
Issue number4-5
DOIs
Publication statusPublished - Apr 1991

Keywords

  • Duchenne muscular dystrophy
  • Respiration
  • Sleep

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Psychiatry and Mental health
  • Clinical Neurology

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