TY - JOUR
T1 - Nocturnal sleep in multisystem atrophy with autonomic failure
T2 - Polygraphic findings in ten patients
AU - Manni, R.
AU - Morini, R.
AU - Martignoni, E.
AU - Pacchetti, C.
AU - Micieli, G.
AU - Tartara, A.
PY - 1993
Y1 - 1993
N2 - A nocturnal polysomnographic study with infrared video-monitoring was performed in ten patients with multisystem atrophy with autonomic failure (MSA-AF) (seven males, three females; median age: 54 years), selected irrespective of the presence of sleep complaints. The MSA-AF patients showed disrupted sleep patterns. Quantitative and qualitative alterations of REM sleep were found, some of which resembled those seen in patients with REM sleep behaviour syndrome. However, only one patient reported episodes of REM behaviour. Six patients showed arterial oxyhaemoglobin (HbS(a)O2) drops below 90% during sleep in relation to recurrent apnoeas or hypopnoeas (HbS(a)O2 nadir 70%). The apnoea hypopnoea index was above the upper limit of the normal range in three of these patients in the absence of obesity of bronchopulmonary diseases. Among patients with sleep-related breathing impairment, laryngeal stridor (three cases) or snoring (one case) were observed. Patients with sleep-related breathing disorders (SBD) exhibited a higher degree of autonomic dysfunction than patients without SBD.
AB - A nocturnal polysomnographic study with infrared video-monitoring was performed in ten patients with multisystem atrophy with autonomic failure (MSA-AF) (seven males, three females; median age: 54 years), selected irrespective of the presence of sleep complaints. The MSA-AF patients showed disrupted sleep patterns. Quantitative and qualitative alterations of REM sleep were found, some of which resembled those seen in patients with REM sleep behaviour syndrome. However, only one patient reported episodes of REM behaviour. Six patients showed arterial oxyhaemoglobin (HbS(a)O2) drops below 90% during sleep in relation to recurrent apnoeas or hypopnoeas (HbS(a)O2 nadir 70%). The apnoea hypopnoea index was above the upper limit of the normal range in three of these patients in the absence of obesity of bronchopulmonary diseases. Among patients with sleep-related breathing impairment, laryngeal stridor (three cases) or snoring (one case) were observed. Patients with sleep-related breathing disorders (SBD) exhibited a higher degree of autonomic dysfunction than patients without SBD.
KW - Autonomic failure
KW - Multisystem atrophy
KW - Sleep apnoea
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M3 - Article
AN - SCOPUS:0027506106
VL - 1
SP - 247
EP - 248
JO - European Spine Journal
JF - European Spine Journal
SN - 0940-6719
IS - 4
ER -