Nodular heterotopia: A neuropathological study of 24 patients undergoing surgery for drug-resistant epilepsy

Alessandra Meroni, Carlo Galli, Manuela Bramerio, Laura Tassi, Nadia Colombo, Massimo Cossu, Giorgio Lo Russo, Rita Garbelli, Roberto Spreafico

Research output: Contribution to journalArticlepeer-review


Purpose: Despite the availability of detailed electroclinical and imaging data, only a few neuropathological studies of nodular heterotopia have been published. The aim of this study was to describe the neuropathological features of various types of nodular heterotopia obtained from patients undergoing surgery for intractable epilepsy. Methods: Specimens of heterotopic nodules taken from 24 patients were neuropathologically investigated using routine and immunocytochemical procedures, and the data were compared with magnetic resonance imaging (MRI), electroclinical findings, and surgical outcomes. Results: The neuropathological data distinguished two groups. Group 1 (14 patients, 78% in Engel class 1) had similar characteristics regardless of the size, number, or location of the nodules, with both projecting and local circuit neurons in the nodules intermingled with glial cells. Thirteen patients had focal cortical dysplasia. The nodules were identified by MRI in all cases. In group 2 (10 patients, 90% in Engel class 1), all of the nodules were within the temporal lobe and associated with hippocampal sclerosis or gangliogliomas. They were very small (undetected by MRI) and mainly formed by projecting neurons with no evidence of glial cells. All of the patients had cortical dysplasia. Discussion: The distinctive neuropathological features of the nodules in the two groups suggest different etiopathogenetic mechanisms. In group 2, the presence of nodular formations in association with cortical dysplasia and either hippocampal sclerosis or ganglioglioma raises a question concerning so-called dual pathology in the temporal lobe.

Original languageEnglish
Pages (from-to)116-124
Number of pages9
Issue number1
Publication statusPublished - Jan 2009


  • Dual pathology
  • Neuropathology of epilepsy
  • Nodular heterotopia

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology


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