Nodular lymphoma eventuating into lymphoplasmocytic lymphoma with monoclonal IgM/λ cold agglutinin and bence-jones proteinuria

E. Pascali, A. Pezzoli, M. Melato, G. Falconieri

Research output: Contribution to journalArticle


A case of nodular lymphocytic (centroblastic/centrocytic) lymphoma that developed within 5 months after the initial diagnosis of lymphoplasmocytic lymphoma is described. The change in the histopathological picture, consisting of the development of a functionally more differentiated B cell neoplasm, occurred in the abdominal lymph nodes while the original pattern persisted in the bone marrow, liver and spleen. The patient was also found to have a serum IgM/ λ monoclonal immunoglobulin exhibiting cold agglutinin activity with specificity for the ‘non-I’ erythrocyte antigens.

Original languageEnglish
Pages (from-to)94-102
Number of pages9
JournalActa Haematologica
Issue number2
Publication statusPublished - 1980



  • Cold agglutinins
  • Lymphoplasmocytic lymphoma
  • Monoclonal gammopathy
  • Nodular lymphoma

ASJC Scopus subject areas

  • Hematology

Cite this