Nodular macroglossia with combined light chain and beta-2 microglobulin deposition in a long-term dialysis patient

Sandro Bandini, Franco Bergesio, Paolo Conti, Giovanni Mancini, Cinzia Cerretini, Calogero Cirami, Alberto Rosati, Gian Marco Caselli, Eloisa Arbustini, Giampaolo Merlini, Giuseppe Ficarra, Maurizio Salvadori

Research output: Contribution to journalArticle

Abstract

We describe a case in which nodular macroglossia, a very rare type of tongue involvement, was associated with the co-deposition of lambda light chain and beta-2 microglobulin fibrils in the tongue. The combined presence of two different amyloid fibrils did not lead to a more unfavourable clinical outcome. We believe that both these features often remain underdiagnosed and are in fact more frequent than reported. A careful clinical examination of the tongue together with serum immunofixation should be routine in all patients with dialysis-related amyloidosis in order to investigate the prevalence and type of tongue involvement and to rule out other types of amyloidosis. In all cases of suspected mixed amyloidosis, immunohistochemical characterization of fibrils should be carried out by electron microscopy.

Original languageEnglish
Pages (from-to)128-131
Number of pages4
JournalJournal of Nephrology
Volume14
Issue number2
Publication statusPublished - Mar 2001

Keywords

  • AL amyloidosis
  • Beta-2 microglobulin
  • Dialysis-related amyloidosis
  • Macroglossia

ASJC Scopus subject areas

  • Nephrology

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    Bandini, S., Bergesio, F., Conti, P., Mancini, G., Cerretini, C., Cirami, C., Rosati, A., Caselli, G. M., Arbustini, E., Merlini, G., Ficarra, G., & Salvadori, M. (2001). Nodular macroglossia with combined light chain and beta-2 microglobulin deposition in a long-term dialysis patient. Journal of Nephrology, 14(2), 128-131.