Nomogram-based prediction of overall survival after regional lymph node dissection and the role of perioperative chemotherapy in penile squamous cell carcinoma: A retrospective multicenter study

Andrea Necchi, Salvatore Lo Vullo, Luigi Mariani, Yao Zhu, Ding Wei Ye, Antonio A. Ornellas, Nick Watkin, Michael Ager, Oliver W. Hakenberg, Axel Heidenreich, Daniele Raggi, Mario Catanzaro, Roberto Salvioni, Juan Chipollini, Mounsif Azizi, Philippe E. Spiess

Research output: Contribution to journalArticle

Abstract

Objectives: To improve the prognostic allocation of patients with penile squamous-cell carcinoma (PSCC) receiving regional lymph node dissection (LND). Patients and methods: An international, multicenter, retrospective study was performed on patients with PSCC who received regional LND, with or without perioperative therapy, from 1980 to 2017. We first used a random forest (RF) method with missing data imputation. Additionally, data were modeled using Cox proportional hazard regression, and a Cox model was also fit including prespecified variables. Based on the latter model, a nomogram for estimating 12-month and 24-month overall survival (OS) was developed. Results: There were 743 patients who received LND at 7 referral centers from Europe, the USA, Brazil, and China. Of these patients, 689 were analyzed: 86 (12.5%) received neoadjuvant chemotherapy (NAC); 171 (24.8%) received adjuvant chemotherapy (AC), and 74 (10.7%) received adjuvant radiotherapy. The variables significantly associated with OS were age (P < 0.001), the pathologically involved/total removed LN ratio (P < 0.001), pN stage (overall P < 0.001), and NAC (P = 0.013). NAC and AC were ineffective in N1-2 patients (clinical and pathological, respectively), whereas they provided OS improvements in N3 patients. Finally, we developed a nomogram predicting 12- and 24-month OS based on prespecified variables (c-index: 0.75). The study is limited by its retrospective nature. Conclusions: We propose a tool that can be offered as an aid to physicians to enhance decision-making, clinical research, and patient counseling whenever LND is needed for PSCC. Administration of NAC and AC should be restricted to clinical and pathological N3 patients, respectively.

Original languageEnglish
Pages (from-to)531.e7-531.e15
JournalUrologic Oncology: Seminars and Original Investigations
Volume37
Issue number8
DOIs
Publication statusPublished - Aug 2019

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Nomograms
Lymph Node Excision
Multicenter Studies
Squamous Cell Carcinoma
Retrospective Studies
Drug Therapy
Survival
Adjuvant Chemotherapy
Adjuvant Radiotherapy
Proportional Hazards Models
Brazil
Counseling
China
Referral and Consultation
Physicians

Keywords

  • Lymph node dissection
  • Nomogram
  • Overall survival
  • Penile squamous-cell carcinoma
  • Prognosis

ASJC Scopus subject areas

  • Oncology
  • Urology

Cite this

Nomogram-based prediction of overall survival after regional lymph node dissection and the role of perioperative chemotherapy in penile squamous cell carcinoma : A retrospective multicenter study. / Necchi, Andrea; Lo Vullo, Salvatore; Mariani, Luigi; Zhu, Yao; Ye, Ding Wei; Ornellas, Antonio A.; Watkin, Nick; Ager, Michael; Hakenberg, Oliver W.; Heidenreich, Axel; Raggi, Daniele; Catanzaro, Mario; Salvioni, Roberto; Chipollini, Juan; Azizi, Mounsif; Spiess, Philippe E.

In: Urologic Oncology: Seminars and Original Investigations, Vol. 37, No. 8, 08.2019, p. 531.e7-531.e15.

Research output: Contribution to journalArticle

Necchi, Andrea ; Lo Vullo, Salvatore ; Mariani, Luigi ; Zhu, Yao ; Ye, Ding Wei ; Ornellas, Antonio A. ; Watkin, Nick ; Ager, Michael ; Hakenberg, Oliver W. ; Heidenreich, Axel ; Raggi, Daniele ; Catanzaro, Mario ; Salvioni, Roberto ; Chipollini, Juan ; Azizi, Mounsif ; Spiess, Philippe E. / Nomogram-based prediction of overall survival after regional lymph node dissection and the role of perioperative chemotherapy in penile squamous cell carcinoma : A retrospective multicenter study. In: Urologic Oncology: Seminars and Original Investigations. 2019 ; Vol. 37, No. 8. pp. 531.e7-531.e15.
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abstract = "Objectives: To improve the prognostic allocation of patients with penile squamous-cell carcinoma (PSCC) receiving regional lymph node dissection (LND). Patients and methods: An international, multicenter, retrospective study was performed on patients with PSCC who received regional LND, with or without perioperative therapy, from 1980 to 2017. We first used a random forest (RF) method with missing data imputation. Additionally, data were modeled using Cox proportional hazard regression, and a Cox model was also fit including prespecified variables. Based on the latter model, a nomogram for estimating 12-month and 24-month overall survival (OS) was developed. Results: There were 743 patients who received LND at 7 referral centers from Europe, the USA, Brazil, and China. Of these patients, 689 were analyzed: 86 (12.5{\%}) received neoadjuvant chemotherapy (NAC); 171 (24.8{\%}) received adjuvant chemotherapy (AC), and 74 (10.7{\%}) received adjuvant radiotherapy. The variables significantly associated with OS were age (P < 0.001), the pathologically involved/total removed LN ratio (P < 0.001), pN stage (overall P < 0.001), and NAC (P = 0.013). NAC and AC were ineffective in N1-2 patients (clinical and pathological, respectively), whereas they provided OS improvements in N3 patients. Finally, we developed a nomogram predicting 12- and 24-month OS based on prespecified variables (c-index: 0.75). The study is limited by its retrospective nature. Conclusions: We propose a tool that can be offered as an aid to physicians to enhance decision-making, clinical research, and patient counseling whenever LND is needed for PSCC. Administration of NAC and AC should be restricted to clinical and pathological N3 patients, respectively.",
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T1 - Nomogram-based prediction of overall survival after regional lymph node dissection and the role of perioperative chemotherapy in penile squamous cell carcinoma

T2 - A retrospective multicenter study

AU - Necchi, Andrea

AU - Lo Vullo, Salvatore

AU - Mariani, Luigi

AU - Zhu, Yao

AU - Ye, Ding Wei

AU - Ornellas, Antonio A.

AU - Watkin, Nick

AU - Ager, Michael

AU - Hakenberg, Oliver W.

AU - Heidenreich, Axel

AU - Raggi, Daniele

AU - Catanzaro, Mario

AU - Salvioni, Roberto

AU - Chipollini, Juan

AU - Azizi, Mounsif

AU - Spiess, Philippe E.

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N2 - Objectives: To improve the prognostic allocation of patients with penile squamous-cell carcinoma (PSCC) receiving regional lymph node dissection (LND). Patients and methods: An international, multicenter, retrospective study was performed on patients with PSCC who received regional LND, with or without perioperative therapy, from 1980 to 2017. We first used a random forest (RF) method with missing data imputation. Additionally, data were modeled using Cox proportional hazard regression, and a Cox model was also fit including prespecified variables. Based on the latter model, a nomogram for estimating 12-month and 24-month overall survival (OS) was developed. Results: There were 743 patients who received LND at 7 referral centers from Europe, the USA, Brazil, and China. Of these patients, 689 were analyzed: 86 (12.5%) received neoadjuvant chemotherapy (NAC); 171 (24.8%) received adjuvant chemotherapy (AC), and 74 (10.7%) received adjuvant radiotherapy. The variables significantly associated with OS were age (P < 0.001), the pathologically involved/total removed LN ratio (P < 0.001), pN stage (overall P < 0.001), and NAC (P = 0.013). NAC and AC were ineffective in N1-2 patients (clinical and pathological, respectively), whereas they provided OS improvements in N3 patients. Finally, we developed a nomogram predicting 12- and 24-month OS based on prespecified variables (c-index: 0.75). The study is limited by its retrospective nature. Conclusions: We propose a tool that can be offered as an aid to physicians to enhance decision-making, clinical research, and patient counseling whenever LND is needed for PSCC. Administration of NAC and AC should be restricted to clinical and pathological N3 patients, respectively.

AB - Objectives: To improve the prognostic allocation of patients with penile squamous-cell carcinoma (PSCC) receiving regional lymph node dissection (LND). Patients and methods: An international, multicenter, retrospective study was performed on patients with PSCC who received regional LND, with or without perioperative therapy, from 1980 to 2017. We first used a random forest (RF) method with missing data imputation. Additionally, data were modeled using Cox proportional hazard regression, and a Cox model was also fit including prespecified variables. Based on the latter model, a nomogram for estimating 12-month and 24-month overall survival (OS) was developed. Results: There were 743 patients who received LND at 7 referral centers from Europe, the USA, Brazil, and China. Of these patients, 689 were analyzed: 86 (12.5%) received neoadjuvant chemotherapy (NAC); 171 (24.8%) received adjuvant chemotherapy (AC), and 74 (10.7%) received adjuvant radiotherapy. The variables significantly associated with OS were age (P < 0.001), the pathologically involved/total removed LN ratio (P < 0.001), pN stage (overall P < 0.001), and NAC (P = 0.013). NAC and AC were ineffective in N1-2 patients (clinical and pathological, respectively), whereas they provided OS improvements in N3 patients. Finally, we developed a nomogram predicting 12- and 24-month OS based on prespecified variables (c-index: 0.75). The study is limited by its retrospective nature. Conclusions: We propose a tool that can be offered as an aid to physicians to enhance decision-making, clinical research, and patient counseling whenever LND is needed for PSCC. Administration of NAC and AC should be restricted to clinical and pathological N3 patients, respectively.

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KW - Overall survival

KW - Penile squamous-cell carcinoma

KW - Prognosis

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