Non-alcoholic fatty liver disease

A multicentre clinical study by the Italian Association for the Study of the Liver

Carmelina Loguercio, T. De Simone, M. V. D'Auria, I. de Sio, A. Federico, C. Tuccillo, A. M. Abbatecola, C. Del Vecchio Blanco, Ernesto Agostinacchio, Antonio Benedetti, Gianluca Svegliati-Baroni, Gabriele Budillon, Lucia Cimino, Maria Chiaramonte, Patrizia Saltarelli, Flavia Fraioli, Silvia Fargion, Anna Ludovica Fracanzani, Annarosa Floreani, Luigi Blasone & 25 others Antonio Grieco, Luca Miele, Gianlodovico Rappaccini, Giovanni Gasbarrini, Paola Loria, Nicola Carulli, Giulio Marchesini, Giampaolo Bianchi, Margherita Matarazzo, Fabrizio Mecenate, Marcello Persico, Fedele De Marino, Piero Portincasa, Vincenzo Palmieri, Giuseppe Palasciano, Aldo Spadaro, Antonino Ajello, Antonella Smedile, Elisabetta Bugianesi, Mario Visconti, Antonio Salvio, Maria Varriale, R. Vecchione, L. M. Terracciano, M. Guido

Research output: Contribution to journalArticle

Abstract

Aim. To define the characteristics of the Italian patient presenting non-alcoholic fatty liver disease. Patients and methods. A total of 305 patients with abnormally high plasma aminotransferase and/or gamma-glutamyl-transpeptidase levels for at least 12 months, with no known cause of chronic liver damage, were consecutively enrolled in the study. Clinical, routine biochemical and liver histology investigations were carried out in all patients. Also evaluated were: (a) oral glucose load; (b) insulinaemia and insulin-resistance using the HOMAtest model; and (c) plasma endotoxaemia, total antioxidant plasma capability, tumour necrosis factor-alpha, plasma interleukin-6 and -10 levels. Malondialdehyde and 4-hydroxynonenal content were determined on liver samples from 120 patients. Results. The majority of patients were young overweight or obese males, with dyslipidaemia (20-60%), diabetes (10.5%), hyperinsulinaemia (40%), hyperferritinaemia (35%). Endotoxaemia was negative in all patients and cytokines were only sporadically altered. Total antioxidant plasma capability was decreased in 38.4% of the patients. Eighty percent of the cases had histological steatosis with a mild degree of inflammation and fibrosis. Seven patients had cirrhosis. Lipid peroxidation markers were increased in 90% of the cases, inversely correlated with fibrosis. Even if at univariate analysis, age, ferritin and tissue 4-hydroxynonenal were independent factors of steatosis (P <0.01), and insulin, HOMA and ferritin of inflammation and fibrosis (P <0.01), at multivariate analysis no single factor was found to be an independent predictor of hepatic lesions. Conclusions. The typical Italian patient with non-alcoholic fatty liver disease is a young male, obese, not diabetic, with a variable incidence of dyslipidaemia and hyperinsulinaemia. Only liver biopsy may define the type of liver damage.

Original languageEnglish
Pages (from-to)398-405
Number of pages8
JournalDigestive and Liver Disease
Volume36
Issue number6
DOIs
Publication statusPublished - Jun 2004

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Multicenter Studies
Liver
Fibrosis
Endotoxemia
Hyperinsulinism
Ferritins
Dyslipidemias
Antioxidants
Non-alcoholic Fatty Liver Disease
Clinical Studies
Inflammation
gamma-Glutamyltransferase
Transaminases
Malondialdehyde
Interleukin-10
Lipid Peroxidation
Insulin Resistance
Interleukin-6
Histology
Multivariate Analysis

Keywords

  • Non-alcoholic fatty liver disease

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Loguercio, C., De Simone, T., D'Auria, M. V., de Sio, I., Federico, A., Tuccillo, C., ... Guido, M. (2004). Non-alcoholic fatty liver disease: A multicentre clinical study by the Italian Association for the Study of the Liver. Digestive and Liver Disease, 36(6), 398-405. https://doi.org/10.1016/j.dld.2004.01.022

Non-alcoholic fatty liver disease : A multicentre clinical study by the Italian Association for the Study of the Liver. / Loguercio, Carmelina; De Simone, T.; D'Auria, M. V.; de Sio, I.; Federico, A.; Tuccillo, C.; Abbatecola, A. M.; Del Vecchio Blanco, C.; Agostinacchio, Ernesto; Benedetti, Antonio; Svegliati-Baroni, Gianluca; Budillon, Gabriele; Cimino, Lucia; Chiaramonte, Maria; Saltarelli, Patrizia; Fraioli, Flavia; Fargion, Silvia; Fracanzani, Anna Ludovica; Floreani, Annarosa; Blasone, Luigi; Grieco, Antonio; Miele, Luca; Rappaccini, Gianlodovico; Gasbarrini, Giovanni; Loria, Paola; Carulli, Nicola; Marchesini, Giulio; Bianchi, Giampaolo; Matarazzo, Margherita; Mecenate, Fabrizio; Persico, Marcello; De Marino, Fedele; Portincasa, Piero; Palmieri, Vincenzo; Palasciano, Giuseppe; Spadaro, Aldo; Ajello, Antonino; Smedile, Antonella; Bugianesi, Elisabetta; Visconti, Mario; Salvio, Antonio; Varriale, Maria; Vecchione, R.; Terracciano, L. M.; Guido, M.

In: Digestive and Liver Disease, Vol. 36, No. 6, 06.2004, p. 398-405.

Research output: Contribution to journalArticle

Loguercio, C, De Simone, T, D'Auria, MV, de Sio, I, Federico, A, Tuccillo, C, Abbatecola, AM, Del Vecchio Blanco, C, Agostinacchio, E, Benedetti, A, Svegliati-Baroni, G, Budillon, G, Cimino, L, Chiaramonte, M, Saltarelli, P, Fraioli, F, Fargion, S, Fracanzani, AL, Floreani, A, Blasone, L, Grieco, A, Miele, L, Rappaccini, G, Gasbarrini, G, Loria, P, Carulli, N, Marchesini, G, Bianchi, G, Matarazzo, M, Mecenate, F, Persico, M, De Marino, F, Portincasa, P, Palmieri, V, Palasciano, G, Spadaro, A, Ajello, A, Smedile, A, Bugianesi, E, Visconti, M, Salvio, A, Varriale, M, Vecchione, R, Terracciano, LM & Guido, M 2004, 'Non-alcoholic fatty liver disease: A multicentre clinical study by the Italian Association for the Study of the Liver', Digestive and Liver Disease, vol. 36, no. 6, pp. 398-405. https://doi.org/10.1016/j.dld.2004.01.022
Loguercio, Carmelina ; De Simone, T. ; D'Auria, M. V. ; de Sio, I. ; Federico, A. ; Tuccillo, C. ; Abbatecola, A. M. ; Del Vecchio Blanco, C. ; Agostinacchio, Ernesto ; Benedetti, Antonio ; Svegliati-Baroni, Gianluca ; Budillon, Gabriele ; Cimino, Lucia ; Chiaramonte, Maria ; Saltarelli, Patrizia ; Fraioli, Flavia ; Fargion, Silvia ; Fracanzani, Anna Ludovica ; Floreani, Annarosa ; Blasone, Luigi ; Grieco, Antonio ; Miele, Luca ; Rappaccini, Gianlodovico ; Gasbarrini, Giovanni ; Loria, Paola ; Carulli, Nicola ; Marchesini, Giulio ; Bianchi, Giampaolo ; Matarazzo, Margherita ; Mecenate, Fabrizio ; Persico, Marcello ; De Marino, Fedele ; Portincasa, Piero ; Palmieri, Vincenzo ; Palasciano, Giuseppe ; Spadaro, Aldo ; Ajello, Antonino ; Smedile, Antonella ; Bugianesi, Elisabetta ; Visconti, Mario ; Salvio, Antonio ; Varriale, Maria ; Vecchione, R. ; Terracciano, L. M. ; Guido, M. / Non-alcoholic fatty liver disease : A multicentre clinical study by the Italian Association for the Study of the Liver. In: Digestive and Liver Disease. 2004 ; Vol. 36, No. 6. pp. 398-405.
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T2 - A multicentre clinical study by the Italian Association for the Study of the Liver

AU - Loguercio, Carmelina

AU - De Simone, T.

AU - D'Auria, M. V.

AU - de Sio, I.

AU - Federico, A.

AU - Tuccillo, C.

AU - Abbatecola, A. M.

AU - Del Vecchio Blanco, C.

AU - Agostinacchio, Ernesto

AU - Benedetti, Antonio

AU - Svegliati-Baroni, Gianluca

AU - Budillon, Gabriele

AU - Cimino, Lucia

AU - Chiaramonte, Maria

AU - Saltarelli, Patrizia

AU - Fraioli, Flavia

AU - Fargion, Silvia

AU - Fracanzani, Anna Ludovica

AU - Floreani, Annarosa

AU - Blasone, Luigi

AU - Grieco, Antonio

AU - Miele, Luca

AU - Rappaccini, Gianlodovico

AU - Gasbarrini, Giovanni

AU - Loria, Paola

AU - Carulli, Nicola

AU - Marchesini, Giulio

AU - Bianchi, Giampaolo

AU - Matarazzo, Margherita

AU - Mecenate, Fabrizio

AU - Persico, Marcello

AU - De Marino, Fedele

AU - Portincasa, Piero

AU - Palmieri, Vincenzo

AU - Palasciano, Giuseppe

AU - Spadaro, Aldo

AU - Ajello, Antonino

AU - Smedile, Antonella

AU - Bugianesi, Elisabetta

AU - Visconti, Mario

AU - Salvio, Antonio

AU - Varriale, Maria

AU - Vecchione, R.

AU - Terracciano, L. M.

AU - Guido, M.

PY - 2004/6

Y1 - 2004/6

N2 - Aim. To define the characteristics of the Italian patient presenting non-alcoholic fatty liver disease. Patients and methods. A total of 305 patients with abnormally high plasma aminotransferase and/or gamma-glutamyl-transpeptidase levels for at least 12 months, with no known cause of chronic liver damage, were consecutively enrolled in the study. Clinical, routine biochemical and liver histology investigations were carried out in all patients. Also evaluated were: (a) oral glucose load; (b) insulinaemia and insulin-resistance using the HOMAtest model; and (c) plasma endotoxaemia, total antioxidant plasma capability, tumour necrosis factor-alpha, plasma interleukin-6 and -10 levels. Malondialdehyde and 4-hydroxynonenal content were determined on liver samples from 120 patients. Results. The majority of patients were young overweight or obese males, with dyslipidaemia (20-60%), diabetes (10.5%), hyperinsulinaemia (40%), hyperferritinaemia (35%). Endotoxaemia was negative in all patients and cytokines were only sporadically altered. Total antioxidant plasma capability was decreased in 38.4% of the patients. Eighty percent of the cases had histological steatosis with a mild degree of inflammation and fibrosis. Seven patients had cirrhosis. Lipid peroxidation markers were increased in 90% of the cases, inversely correlated with fibrosis. Even if at univariate analysis, age, ferritin and tissue 4-hydroxynonenal were independent factors of steatosis (P <0.01), and insulin, HOMA and ferritin of inflammation and fibrosis (P <0.01), at multivariate analysis no single factor was found to be an independent predictor of hepatic lesions. Conclusions. The typical Italian patient with non-alcoholic fatty liver disease is a young male, obese, not diabetic, with a variable incidence of dyslipidaemia and hyperinsulinaemia. Only liver biopsy may define the type of liver damage.

AB - Aim. To define the characteristics of the Italian patient presenting non-alcoholic fatty liver disease. Patients and methods. A total of 305 patients with abnormally high plasma aminotransferase and/or gamma-glutamyl-transpeptidase levels for at least 12 months, with no known cause of chronic liver damage, were consecutively enrolled in the study. Clinical, routine biochemical and liver histology investigations were carried out in all patients. Also evaluated were: (a) oral glucose load; (b) insulinaemia and insulin-resistance using the HOMAtest model; and (c) plasma endotoxaemia, total antioxidant plasma capability, tumour necrosis factor-alpha, plasma interleukin-6 and -10 levels. Malondialdehyde and 4-hydroxynonenal content were determined on liver samples from 120 patients. Results. The majority of patients were young overweight or obese males, with dyslipidaemia (20-60%), diabetes (10.5%), hyperinsulinaemia (40%), hyperferritinaemia (35%). Endotoxaemia was negative in all patients and cytokines were only sporadically altered. Total antioxidant plasma capability was decreased in 38.4% of the patients. Eighty percent of the cases had histological steatosis with a mild degree of inflammation and fibrosis. Seven patients had cirrhosis. Lipid peroxidation markers were increased in 90% of the cases, inversely correlated with fibrosis. Even if at univariate analysis, age, ferritin and tissue 4-hydroxynonenal were independent factors of steatosis (P <0.01), and insulin, HOMA and ferritin of inflammation and fibrosis (P <0.01), at multivariate analysis no single factor was found to be an independent predictor of hepatic lesions. Conclusions. The typical Italian patient with non-alcoholic fatty liver disease is a young male, obese, not diabetic, with a variable incidence of dyslipidaemia and hyperinsulinaemia. Only liver biopsy may define the type of liver damage.

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