Non-Alcoholic Fatty Liver Disease (NAFLD) in children and adolescents with Prader-Willi Syndrome (PWS)

D. Fintini, E. Inzaghi, M. Colajacomo, S. Bocchini, G. Grugni, C. Brufani, M. Cappa, V. Nobili, S. Cianfarani, A. Crinò

Research output: Contribution to journalArticle

Abstract

We tested the hypothesis that patients with Prader-Willi syndrome (PWS) may be at lower risk of developing non-alcoholic fatty liver disease (NAFLD) because of a higher insulin sensitivity. Twenty-one PWS patients and 42 control subjects closely similar for age, gender, pubertal stage and body mass index (CNT), were studied. Metabolic profile and body composition were assessed. NAFLD was established by a validated method of US grading (range from G0 to G3). PWS patients showed a significantly better metabolic profile (lower waist circumference, fasting glucose levels, HOMA-IR, cholesterol, transaminase levels and trunk fat mass/fat mass ratio). Furthermore, NAFLD G1stage was significantly more frequent in PWS subjects (P

Original languageEnglish
JournalPediatric obesity
DOIs
Publication statusAccepted/In press - 2015

Keywords

  • NAFLD
  • Obesity
  • Paediatric
  • Prader-Willi

ASJC Scopus subject areas

  • Health Policy
  • Pediatrics, Perinatology, and Child Health
  • Public Health, Environmental and Occupational Health
  • Nutrition and Dietetics

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