Non-canonical glutamate signaling in a genetic model of migraine with aura

Patrick D. Parker; Pratyush Suryavanshi; Marcello Melone; Punam A. Sawant-Pokam; Katelyn M. Reinhart; Dan Kaufmann; Jeremy J. Theriot; Arianna Pugliese; Fiorenzo Conti; C. William Shuttleworth; Daniela Pietrobon; K. C. Brennan

doi:10.1016/j.neuron.2020.11.018

Non-canonical glutamate signaling in a genetic model of migraine with aura

Patrick D. Parker, Pratyush Suryavanshi, Marcello Melone, Punam A. Sawant-Pokam, Katelyn M. Reinhart, Dan Kaufmann, Jeremy J. Theriot, Arianna Pugliese, Fiorenzo Conti, C. William Shuttleworth, Daniela Pietrobon, K. C. Brennan

Istituto Nazionale di Riposo e Cura per Anziani V.E. II

Research output: Contribution to journal › Article › peer-review

Abstract

Migraine is a common and debilitating neurological disorder whose underlying neurobiology is poorly understood. Parker et al. report “plumes” of glutamate release in a genetic model of migraine that are a consequence of inefficient glutamate clearance. Plumes also precede the onset of spreading depolarization, the physiological correlate of migraine aura.

Original language	English
Journal	Neuron
DOIs	https://doi.org/10.1016/j.neuron.2020.11.018
Publication status	Accepted/In press - 2021

Keywords

astrocyte
cortical spreading depression
familial hemiplegic migraine
glutamate
glutamate transporter
iGluSnFR
spreading depolarization

ASJC Scopus subject areas

Neuroscience(all)

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Non-canonical glutamate signaling in a genetic model of migraine with aura. / Parker, Patrick D.; Suryavanshi, Pratyush; Melone, Marcello; Sawant-Pokam, Punam A.; Reinhart, Katelyn M.; Kaufmann, Dan; Theriot, Jeremy J.; Pugliese, Arianna; Conti, Fiorenzo; Shuttleworth, C. William; Pietrobon, Daniela; Brennan, K. C.

In: Neuron, 2021.

Research output: Contribution to journal › Article › peer-review

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title = "Non-canonical glutamate signaling in a genetic model of migraine with aura",

abstract = "Migraine is a common and debilitating neurological disorder whose underlying neurobiology is poorly understood. Parker et al. report “plumes” of glutamate release in a genetic model of migraine that are a consequence of inefficient glutamate clearance. Plumes also precede the onset of spreading depolarization, the physiological correlate of migraine aura.",

keywords = "astrocyte, cortical spreading depression, familial hemiplegic migraine, glutamate, glutamate transporter, iGluSnFR, spreading depolarization",

author = "Parker, {Patrick D.} and Pratyush Suryavanshi and Marcello Melone and Sawant-Pokam, {Punam A.} and Reinhart, {Katelyn M.} and Dan Kaufmann and Theriot, {Jeremy J.} and Arianna Pugliese and Fiorenzo Conti and Shuttleworth, {C. William} and Daniela Pietrobon and Brennan, {K. C.}",

note = "Funding Information: We thank Giorgio Casari for the FHM2 mice, Nicholas McKean for help with viral injections, Mirko Santello for discussion of results, and Loren L. Looger and the Howard Hughes Medical Institute for providing iGluSnFR to the research community. This work was supported by the National Institutes of Health, United States R01 NS085413 and NS102978 (K.C.B.), F31 NS105531 (P.D.P.), R01 NS106901 and P20 GM109089 (C.W.S.), and T32 HL007736 (K.M.R.); the National Science Foundation, United States GRFP (P.D.P.); and the Telethon Foundation, Italy TI-GGP14234 (D.P.), PRIN 2017ANP5L8 (D.P.), PRIN 2010JFYFY2_006 (F.C. and D.P.), PRIN 2015H4K2CR (F.C.), and PSA PJ040046_2018 (F.C.). Publisher Copyright: {\textcopyright} 2020 The Authors Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",

year = "2021",

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AU - Suryavanshi, Pratyush

AU - Melone, Marcello

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AU - Reinhart, Katelyn M.

AU - Kaufmann, Dan

AU - Theriot, Jeremy J.

AU - Pugliese, Arianna

AU - Conti, Fiorenzo

AU - Shuttleworth, C. William

AU - Pietrobon, Daniela

AU - Brennan, K. C.

N1 - Funding Information: We thank Giorgio Casari for the FHM2 mice, Nicholas McKean for help with viral injections, Mirko Santello for discussion of results, and Loren L. Looger and the Howard Hughes Medical Institute for providing iGluSnFR to the research community. This work was supported by the National Institutes of Health, United States R01 NS085413 and NS102978 (K.C.B.), F31 NS105531 (P.D.P.), R01 NS106901 and P20 GM109089 (C.W.S.), and T32 HL007736 (K.M.R.); the National Science Foundation, United States GRFP (P.D.P.); and the Telethon Foundation, Italy TI-GGP14234 (D.P.), PRIN 2017ANP5L8 (D.P.), PRIN 2010JFYFY2_006 (F.C. and D.P.), PRIN 2015H4K2CR (F.C.), and PSA PJ040046_2018 (F.C.). Publisher Copyright: © 2020 The Authors Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021

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KW - glutamate transporter

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