TY - JOUR
T1 - Non-canonical glutamate signaling in a genetic model of migraine with aura
AU - Parker, Patrick D.
AU - Suryavanshi, Pratyush
AU - Melone, Marcello
AU - Sawant-Pokam, Punam A.
AU - Reinhart, Katelyn M.
AU - Kaufmann, Dan
AU - Theriot, Jeremy J.
AU - Pugliese, Arianna
AU - Conti, Fiorenzo
AU - Shuttleworth, C. William
AU - Pietrobon, Daniela
AU - Brennan, K. C.
N1 - Funding Information:
We thank Giorgio Casari for the FHM2 mice, Nicholas McKean for help with viral injections, Mirko Santello for discussion of results, and Loren L. Looger and the Howard Hughes Medical Institute for providing iGluSnFR to the research community. This work was supported by the National Institutes of Health, United States R01 NS085413 and NS102978 (K.C.B.), F31 NS105531 (P.D.P.), R01 NS106901 and P20 GM109089 (C.W.S.), and T32 HL007736 (K.M.R.); the National Science Foundation, United States GRFP (P.D.P.); and the Telethon Foundation, Italy TI-GGP14234 (D.P.), PRIN 2017ANP5L8 (D.P.), PRIN 2010JFYFY2_006 (F.C. and D.P.), PRIN 2015H4K2CR (F.C.), and PSA PJ040046_2018 (F.C.).
Publisher Copyright:
© 2020 The Authors
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021
Y1 - 2021
N2 - Migraine is a common and debilitating neurological disorder whose underlying neurobiology is poorly understood. Parker et al. report “plumes” of glutamate release in a genetic model of migraine that are a consequence of inefficient glutamate clearance. Plumes also precede the onset of spreading depolarization, the physiological correlate of migraine aura.
AB - Migraine is a common and debilitating neurological disorder whose underlying neurobiology is poorly understood. Parker et al. report “plumes” of glutamate release in a genetic model of migraine that are a consequence of inefficient glutamate clearance. Plumes also precede the onset of spreading depolarization, the physiological correlate of migraine aura.
KW - astrocyte
KW - cortical spreading depression
KW - familial hemiplegic migraine
KW - glutamate
KW - glutamate transporter
KW - iGluSnFR
KW - spreading depolarization
UR - http://www.scopus.com/inward/record.url?scp=85099157019&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85099157019&partnerID=8YFLogxK
U2 - 10.1016/j.neuron.2020.11.018
DO - 10.1016/j.neuron.2020.11.018
M3 - Article
C2 - 33321071
AN - SCOPUS:85099157019
JO - Neuron
JF - Neuron
SN - 0896-6273
ER -