Non-canonical glutamate signaling in a genetic model of migraine with aura

Patrick D. Parker, Pratyush Suryavanshi, Marcello Melone, Punam A. Sawant-Pokam, Katelyn M. Reinhart, Dan Kaufmann, Jeremy J. Theriot, Arianna Pugliese, Fiorenzo Conti, C. William Shuttleworth, Daniela Pietrobon, K. C. Brennan

Research output: Contribution to journalArticlepeer-review

Abstract

Migraine is a common and debilitating neurological disorder whose underlying neurobiology is poorly understood. Parker et al. report “plumes” of glutamate release in a genetic model of migraine that are a consequence of inefficient glutamate clearance. Plumes also precede the onset of spreading depolarization, the physiological correlate of migraine aura.

Original languageEnglish
JournalNeuron
DOIs
Publication statusAccepted/In press - 2021

Keywords

  • astrocyte
  • cortical spreading depression
  • familial hemiplegic migraine
  • glutamate
  • glutamate transporter
  • iGluSnFR
  • spreading depolarization

ASJC Scopus subject areas

  • Neuroscience(all)

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