Migraine is a common and debilitating neurological disorder whose underlying neurobiology is poorly understood. Parker et al. report “plumes” of glutamate release in a genetic model of migraine that are a consequence of inefficient glutamate clearance. Plumes also precede the onset of spreading depolarization, the physiological correlate of migraine aura.
- cortical spreading depression
- familial hemiplegic migraine
- glutamate transporter
- spreading depolarization
ASJC Scopus subject areas