Non- CDH1 -associated familial gastric cancer and epigenetics factors

Marina Leite, Giovanni Corso, Sónia Sousa, Joana Carvalho, Franco Roviello, Carla Oliveira, Ceu Figueiredo, Raquel Seruca

Research output: Chapter in Book/Report/Conference proceedingChapter


This chapter provides an overview of the major epigenetic mechanisms, such as DNA methylation, histone modifi cations, and miRNA, and describes those epigenetic mechanisms that are altered in non- CDH1 associated familial gastric cancer. Moreover, we also discuss the clinical implications of the epigenome characterization for this familial gastric cancer setting, regarding its potential in therapy.

Original languageEnglish
Title of host publicationSpotlight on Familial and Hereditary Gastric Cancer
PublisherSpringer Netherlands
Number of pages15
ISBN (Print)9789400765702, 940076569X, 9789400765696
Publication statusPublished - Feb 1 2013


  • Epigenetics
  • Familial gastric cancer
  • MMR
  • MSI

ASJC Scopus subject areas

  • Medicine(all)


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