Non Celiac Gluten Sensitivity

Maria Teresa Bardella, Luca Elli, Francesca Ferretti

Research output: Contribution to journalReview article

Abstract

Purpose of review: A new syndrome responding to gluten-free diet and defined non-celiac gluten sensitivity entered the spectrum of gluten-related disorders, together with celiac disease and wheat allergy. However, its definition, prevalence, diagnosis, pathogenesis, treatment, and follow up are still controversial. The purpose of the review is to summarize the evidence and problems emerging from the current literature. Recent findings: Direct implication of gluten in the onset of symptoms is often unproved as a low fermentable oligo-, di- and mono-saccharides and polyols diet or other components of cereals as wheat amylase trypsin inhibitor could be similarly involved. To date, no specific biomarkers or histological abnormalities confirm diagnosis, and only the self-reported response to gluten-free diet as well as a positive double blind placebo-gluten challenge characterizes these non-celiac, non-wheat allergic patients. Summary: Critical revision of published studies can offer practical indications in approaching this clinical topic and useful suggestions to standardize scientific researches.

Original languageEnglish
Article number63
JournalCurrent Gastroenterology Reports
Volume18
Issue number12
DOIs
Publication statusPublished - Dec 1 2016

Fingerprint

Glutens
Abdomen
Gluten-Free Diet
Wheat Hypersensitivity
Trypsin Inhibitors
Celiac Disease
Amylases
Triticum
Biomarkers
Placebos
Diet
Research
Therapeutics

Keywords

  • Celiac disease
  • Double-blind placebo-controlled challenge
  • Gluten-free diet
  • Irritable bowel syndrome
  • Non-celiac gluten sensitivity
  • Wheat sensitivity

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Non Celiac Gluten Sensitivity. / Bardella, Maria Teresa; Elli, Luca; Ferretti, Francesca.

In: Current Gastroenterology Reports, Vol. 18, No. 12, 63, 01.12.2016.

Research output: Contribution to journalReview article

Bardella, Maria Teresa ; Elli, Luca ; Ferretti, Francesca. / Non Celiac Gluten Sensitivity. In: Current Gastroenterology Reports. 2016 ; Vol. 18, No. 12.
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