Non-Cell-Autonomous Regulation of Cellular Senescence in Cancer

Diletta Di Mitri, Andrea Alimonti

Research output: Contribution to journalArticlepeer-review

Abstract

Cellular senescence is a permanent growth arrest that is broadly recognized to act as a barrier against tumorigenesis. Senescence is predominant in premalignant tumors, and senescence escape is thought to be required for tumor progression. Importantly, evidences indicate that cell-autonomous mechanisms, such as genetic alterations or therapeutic interventions targeting specific genetic pathways, can affect the senescence response in cancer. Nevertheless, new findings have emerged in the last few years that indicate a fundamental role for the tumor microenvironment in the regulation of cellular senescence. Indeed, cytokines belonging to the senescent secretome, as well as tumor-infiltrating immune subsets, have been described to modulate the senescence response in tumors. Such evidence demonstrates that senescence initiation also relies on non-cell-autonomous mechanisms, which are discussed in the present review.

Original languageEnglish
Pages (from-to)215-226
Number of pages12
JournalTrends in Cell Biology
Volume26
Issue number3
DOIs
Publication statusPublished - Mar 1 2016
Externally publishedYes

Keywords

  • SASP
  • Senescence
  • Tumor immune microenvironment

ASJC Scopus subject areas

  • Cell Biology

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