Non-cirrhotic thrombocytopenic patients with hepatitis C virus: Characteristics and outcome of antiviral therapy

Edoardo G. Giannini; Nezam H. Afdhal; Samuel H. Sigal; Andrew J. Muir; K. Rajender Reddy; Shanthi Vijayaraghavan; Magdy Elkashab; Manuel Romero-Gómez; Geoffrey M. Dusheiko; Malini Iyengar; Sandra Y. Vasey; Fiona M. Campbell; Dickens Theodore

doi:10.1111/jgh.12942

Non-cirrhotic thrombocytopenic patients with hepatitis C virus: Characteristics and outcome of antiviral therapy

Edoardo G. Giannini, Nezam H. Afdhal, Samuel H. Sigal, Andrew J. Muir, K. Rajender Reddy, Shanthi Vijayaraghavan, Magdy Elkashab, Manuel Romero-Gómez, Geoffrey M. Dusheiko, Malini Iyengar, Sandra Y. Vasey, Fiona M. Campbell, Dickens Theodore

A.O.U. San Martino - IST, Istituto Nazionale Ricerca sul Cancro (GENOVA)

Research output: Contribution to journal › Article › peer-review

Abstract

Background and Aim: Thrombocytopenia is frequently observed in patients with chronic hepatitis C virus (HCV) infection and cirrhosis, although it can also be observed in patients without cirrhosis by a virus-mediated phenomenon. This study assessed the prevalence, characteristics, and outcomes of antiviral therapy in patients with chronic HCV infection and thrombocytopenia not associated with cirrhosis. Methods: The study included 1268 patients with HCV infection and thrombocytopenia enrolled in the phase 3 ENABLE studies that assessed the impact of eltrombopag on achieving a sustained virologic response to pegylated interferon and ribavirin. The study population was subdivided according to baseline FibroSURE test results into patients with non-cirrhosis (FibroSURE

Original language	English
Pages (from-to)	1301-1308
Number of pages	8
Journal	Journal of Gastroenterology and Hepatology
Volume	30
Issue number	8
DOIs	https://doi.org/10.1111/jgh.12942
Publication status	Published - Aug 1 2015

Keywords

Cirrhosis
Eltrombopag
Hepatitis C virus
Interferon
Platelets

ASJC Scopus subject areas

Gastroenterology
Hepatology

Access to Document

10.1111/jgh.12942

Fingerprint Dive into the research topics of 'Non-cirrhotic thrombocytopenic patients with hepatitis C virus: Characteristics and outcome of antiviral therapy'. Together they form a unique fingerprint.

Cite this

Giannini, E. G., Afdhal, N. H., Sigal, S. H., Muir, A. J., Reddy, K. R., Vijayaraghavan, S., Elkashab, M., Romero-Gómez, M., Dusheiko, G. M., Iyengar, M., Vasey, S. Y., Campbell, F. M., & Theodore, D. (2015). Non-cirrhotic thrombocytopenic patients with hepatitis C virus: Characteristics and outcome of antiviral therapy. Journal of Gastroenterology and Hepatology, 30(8), 1301-1308. https://doi.org/10.1111/jgh.12942

Non-cirrhotic thrombocytopenic patients with hepatitis C virus : Characteristics and outcome of antiviral therapy. / Giannini, Edoardo G.; Afdhal, Nezam H.; Sigal, Samuel H.; Muir, Andrew J.; Reddy, K. Rajender; Vijayaraghavan, Shanthi; Elkashab, Magdy; Romero-Gómez, Manuel; Dusheiko, Geoffrey M.; Iyengar, Malini; Vasey, Sandra Y.; Campbell, Fiona M.; Theodore, Dickens.

In: Journal of Gastroenterology and Hepatology, Vol. 30, No. 8, 01.08.2015, p. 1301-1308.

Research output: Contribution to journal › Article › peer-review

Giannini, EG, Afdhal, NH, Sigal, SH, Muir, AJ, Reddy, KR, Vijayaraghavan, S, Elkashab, M, Romero-Gómez, M, Dusheiko, GM, Iyengar, M, Vasey, SY, Campbell, FM & Theodore, D 2015, 'Non-cirrhotic thrombocytopenic patients with hepatitis C virus: Characteristics and outcome of antiviral therapy', Journal of Gastroenterology and Hepatology, vol. 30, no. 8, pp. 1301-1308. https://doi.org/10.1111/jgh.12942

Giannini, Edoardo G. ; Afdhal, Nezam H. ; Sigal, Samuel H. ; Muir, Andrew J. ; Reddy, K. Rajender ; Vijayaraghavan, Shanthi ; Elkashab, Magdy ; Romero-Gómez, Manuel ; Dusheiko, Geoffrey M. ; Iyengar, Malini ; Vasey, Sandra Y. ; Campbell, Fiona M. ; Theodore, Dickens. / Non-cirrhotic thrombocytopenic patients with hepatitis C virus : Characteristics and outcome of antiviral therapy. In: Journal of Gastroenterology and Hepatology. 2015 ; Vol. 30, No. 8. pp. 1301-1308.

@article{37876112874e4cd98853ed1fb4b44ea7,

title = "Non-cirrhotic thrombocytopenic patients with hepatitis C virus: Characteristics and outcome of antiviral therapy",

abstract = "Background and Aim: Thrombocytopenia is frequently observed in patients with chronic hepatitis C virus (HCV) infection and cirrhosis, although it can also be observed in patients without cirrhosis by a virus-mediated phenomenon. This study assessed the prevalence, characteristics, and outcomes of antiviral therapy in patients with chronic HCV infection and thrombocytopenia not associated with cirrhosis. Methods: The study included 1268 patients with HCV infection and thrombocytopenia enrolled in the phase 3 ENABLE studies that assessed the impact of eltrombopag on achieving a sustained virologic response to pegylated interferon and ribavirin. The study population was subdivided according to baseline FibroSURE test results into patients with non-cirrhosis (FibroSURE",

keywords = "Cirrhosis, Eltrombopag, Hepatitis C virus, Interferon, Platelets",

author = "Giannini, {Edoardo G.} and Afdhal, {Nezam H.} and Sigal, {Samuel H.} and Muir, {Andrew J.} and Reddy, {K. Rajender} and Shanthi Vijayaraghavan and Magdy Elkashab and Manuel Romero-G{\'o}mez and Dusheiko, {Geoffrey M.} and Malini Iyengar and Vasey, {Sandra Y.} and Campbell, {Fiona M.} and Dickens Theodore",

year = "2015",

month = aug,

day = "1",

doi = "10.1111/jgh.12942",

language = "English",

volume = "30",

pages = "1301--1308",

journal = "Journal of Gastroenterology and Hepatology (Australia)",

issn = "0815-9319",

publisher = "Wiley-Blackwell",

number = "8",

}

TY - JOUR

T1 - Non-cirrhotic thrombocytopenic patients with hepatitis C virus

T2 - Characteristics and outcome of antiviral therapy

AU - Giannini, Edoardo G.

AU - Afdhal, Nezam H.

AU - Sigal, Samuel H.

AU - Muir, Andrew J.

AU - Reddy, K. Rajender

AU - Vijayaraghavan, Shanthi

AU - Elkashab, Magdy

AU - Romero-Gómez, Manuel

AU - Dusheiko, Geoffrey M.

AU - Iyengar, Malini

AU - Vasey, Sandra Y.

AU - Campbell, Fiona M.

AU - Theodore, Dickens

PY - 2015/8/1

Y1 - 2015/8/1

N2 - Background and Aim: Thrombocytopenia is frequently observed in patients with chronic hepatitis C virus (HCV) infection and cirrhosis, although it can also be observed in patients without cirrhosis by a virus-mediated phenomenon. This study assessed the prevalence, characteristics, and outcomes of antiviral therapy in patients with chronic HCV infection and thrombocytopenia not associated with cirrhosis. Methods: The study included 1268 patients with HCV infection and thrombocytopenia enrolled in the phase 3 ENABLE studies that assessed the impact of eltrombopag on achieving a sustained virologic response to pegylated interferon and ribavirin. The study population was subdivided according to baseline FibroSURE test results into patients with non-cirrhosis (FibroSURE

AB - Background and Aim: Thrombocytopenia is frequently observed in patients with chronic hepatitis C virus (HCV) infection and cirrhosis, although it can also be observed in patients without cirrhosis by a virus-mediated phenomenon. This study assessed the prevalence, characteristics, and outcomes of antiviral therapy in patients with chronic HCV infection and thrombocytopenia not associated with cirrhosis. Methods: The study included 1268 patients with HCV infection and thrombocytopenia enrolled in the phase 3 ENABLE studies that assessed the impact of eltrombopag on achieving a sustained virologic response to pegylated interferon and ribavirin. The study population was subdivided according to baseline FibroSURE test results into patients with non-cirrhosis (FibroSURE

KW - Cirrhosis

KW - Eltrombopag

KW - Hepatitis C virus

KW - Interferon

KW - Platelets

UR - http://www.scopus.com/inward/record.url?scp=84937403243&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84937403243&partnerID=8YFLogxK

U2 - 10.1111/jgh.12942

DO - 10.1111/jgh.12942

M3 - Article

C2 - 25777337

AN - SCOPUS:84937403243

VL - 30

SP - 1301

EP - 1308

JO - Journal of Gastroenterology and Hepatology (Australia)

JF - Journal of Gastroenterology and Hepatology (Australia)

SN - 0815-9319

IS - 8

ER -