Non classical complications of primary hyperparathyroidism

I. Chiodini, E. Cairoli, S. Palmieri, J. Pepe, M. D. Walker

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Several studies suggested that the condition of primary hyperparathyroidism (PHPT) may be associated not only with the classical bone, kidney and gastrointestinal consequences, but also with cardiovascular, neuromuscular and articular complications, impaired quality of life and increased cancer risk. However, the only cardiovascular complications associated with PHPT, which seems to improve after parathyroidectomy, is left ventricular hypertrophy, while, data regarding the reversibility of hypertension, valve calcifications and increased vascular stiffness are inconsistent. Parathyroidectomy seems to ameliorate neuropsychological, cognitive disturbances and quality of life in moderate-severe PHPT, while data in mild PHPT are less clear. At variance, the effect of parathyroidectomy on neuromuscular and articular complications is still unknown, and no studies demonstrated a reduction of cancer risk after recovery from PHPT. Overall, to date, cardiovascular and neuropsychological evaluation are not recommended solely because of PHPT, nor cardiovascular disease, muscle weakness, and neuropsychological complications are indication for parathyroidectomy.

Original languageEnglish
Pages (from-to)805-820
JournalBest Practice and Research: Clinical Endocrinology and Metabolism
Volume32
Issue number6
DOIs
Publication statusPublished - 2018

Fingerprint

Primary Hyperparathyroidism
Parathyroidectomy
Joints
Quality of Life
Vascular Stiffness
Muscle Weakness
Left Ventricular Hypertrophy
Risk Reduction Behavior
Neoplasms
Cardiovascular Diseases
Hypertension
Kidney
Bone and Bones

Keywords

  • cancer risk
  • cardiovascular disease
  • neuromuscular manifestations
  • neuropsychological disturbances
  • primary hyperparathyroidism

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Non classical complications of primary hyperparathyroidism. / Chiodini, I.; Cairoli, E.; Palmieri, S.; Pepe, J.; Walker, M. D.

In: Best Practice and Research: Clinical Endocrinology and Metabolism, Vol. 32, No. 6, 2018, p. 805-820.

Research output: Contribution to journalArticle

Chiodini, I. ; Cairoli, E. ; Palmieri, S. ; Pepe, J. ; Walker, M. D. / Non classical complications of primary hyperparathyroidism. In: Best Practice and Research: Clinical Endocrinology and Metabolism. 2018 ; Vol. 32, No. 6. pp. 805-820.
@article{b1c42de144284037a2ef52dbd45ed45e,
title = "Non classical complications of primary hyperparathyroidism",
abstract = "Several studies suggested that the condition of primary hyperparathyroidism (PHPT) may be associated not only with the classical bone, kidney and gastrointestinal consequences, but also with cardiovascular, neuromuscular and articular complications, impaired quality of life and increased cancer risk. However, the only cardiovascular complications associated with PHPT, which seems to improve after parathyroidectomy, is left ventricular hypertrophy, while, data regarding the reversibility of hypertension, valve calcifications and increased vascular stiffness are inconsistent. Parathyroidectomy seems to ameliorate neuropsychological, cognitive disturbances and quality of life in moderate-severe PHPT, while data in mild PHPT are less clear. At variance, the effect of parathyroidectomy on neuromuscular and articular complications is still unknown, and no studies demonstrated a reduction of cancer risk after recovery from PHPT. Overall, to date, cardiovascular and neuropsychological evaluation are not recommended solely because of PHPT, nor cardiovascular disease, muscle weakness, and neuropsychological complications are indication for parathyroidectomy.",
keywords = "cancer risk, cardiovascular disease, neuromuscular manifestations, neuropsychological disturbances, primary hyperparathyroidism",
author = "I. Chiodini and E. Cairoli and S. Palmieri and J. Pepe and Walker, {M. D.}",
year = "2018",
doi = "10.1016/j.beem.2018.06.006",
language = "English",
volume = "32",
pages = "805--820",
journal = "Best Practice and Research in Clinical Endocrinology and Metabolism",
issn = "1521-690X",
publisher = "Bailliere Tindall Ltd",
number = "6",

}

TY - JOUR

T1 - Non classical complications of primary hyperparathyroidism

AU - Chiodini, I.

AU - Cairoli, E.

AU - Palmieri, S.

AU - Pepe, J.

AU - Walker, M. D.

PY - 2018

Y1 - 2018

N2 - Several studies suggested that the condition of primary hyperparathyroidism (PHPT) may be associated not only with the classical bone, kidney and gastrointestinal consequences, but also with cardiovascular, neuromuscular and articular complications, impaired quality of life and increased cancer risk. However, the only cardiovascular complications associated with PHPT, which seems to improve after parathyroidectomy, is left ventricular hypertrophy, while, data regarding the reversibility of hypertension, valve calcifications and increased vascular stiffness are inconsistent. Parathyroidectomy seems to ameliorate neuropsychological, cognitive disturbances and quality of life in moderate-severe PHPT, while data in mild PHPT are less clear. At variance, the effect of parathyroidectomy on neuromuscular and articular complications is still unknown, and no studies demonstrated a reduction of cancer risk after recovery from PHPT. Overall, to date, cardiovascular and neuropsychological evaluation are not recommended solely because of PHPT, nor cardiovascular disease, muscle weakness, and neuropsychological complications are indication for parathyroidectomy.

AB - Several studies suggested that the condition of primary hyperparathyroidism (PHPT) may be associated not only with the classical bone, kidney and gastrointestinal consequences, but also with cardiovascular, neuromuscular and articular complications, impaired quality of life and increased cancer risk. However, the only cardiovascular complications associated with PHPT, which seems to improve after parathyroidectomy, is left ventricular hypertrophy, while, data regarding the reversibility of hypertension, valve calcifications and increased vascular stiffness are inconsistent. Parathyroidectomy seems to ameliorate neuropsychological, cognitive disturbances and quality of life in moderate-severe PHPT, while data in mild PHPT are less clear. At variance, the effect of parathyroidectomy on neuromuscular and articular complications is still unknown, and no studies demonstrated a reduction of cancer risk after recovery from PHPT. Overall, to date, cardiovascular and neuropsychological evaluation are not recommended solely because of PHPT, nor cardiovascular disease, muscle weakness, and neuropsychological complications are indication for parathyroidectomy.

KW - cancer risk

KW - cardiovascular disease

KW - neuromuscular manifestations

KW - neuropsychological disturbances

KW - primary hyperparathyroidism

UR - http://www.scopus.com/inward/record.url?scp=85049109231&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85049109231&partnerID=8YFLogxK

U2 - 10.1016/j.beem.2018.06.006

DO - 10.1016/j.beem.2018.06.006

M3 - Article

AN - SCOPUS:85049109231

VL - 32

SP - 805

EP - 820

JO - Best Practice and Research in Clinical Endocrinology and Metabolism

JF - Best Practice and Research in Clinical Endocrinology and Metabolism

SN - 1521-690X

IS - 6

ER -