TY - JOUR
T1 - Non-classical MHC-I human leukocyte antigen (HLA-G) in hepatotropic viral infections and in hepatocellular carcinoma
AU - Catamo, Eulalia
AU - Zupin, Luisa
AU - Crovella, Sergio
AU - Celsi, Fulvio
AU - Segat, Ludovica
PY - 2014
Y1 - 2014
N2 - The human leukocyte antigen (HLA)-. G is a "nonclassical" major histocompatibility complex (MHC) class Ib gene, located at chromosome 6, in the 6p21.3 region.The HLA-G presents immunomodulatory functions essential in pregnancy for the tolerance of the semi-allogenic fetus, but an abnormal expression of HLA-G has been observed in numerous pathological conditions, such as tumors, autoimmune diseases and viral infections. In recent years, numerous studies have assessed the clinical relevance of HLA-G expression in different types of cancer: in general, a higher HLA-G expression correlates with a lower survival rate or a shorter disease-free survival.Altered expression of HLA-G has been found in both HCV and HBV infection, and some genetic polymorphisms have been associated with altered susceptibility/disease development for these infections, however, whether the biologic role of HLA-G in HCV and HBV infection is beneficial or hazardous, it is not completely clear. In the context of hepatocellular carcinoma, HLA-G has shown a potential diagnostic role, moreover a prognostic value in HCC patients has been also attributed to HLA-G molecules.We revise here the role of HLA-G in hepatotropic HBV/HCV infections and in hepatocellular carcinoma (HCC).
AB - The human leukocyte antigen (HLA)-. G is a "nonclassical" major histocompatibility complex (MHC) class Ib gene, located at chromosome 6, in the 6p21.3 region.The HLA-G presents immunomodulatory functions essential in pregnancy for the tolerance of the semi-allogenic fetus, but an abnormal expression of HLA-G has been observed in numerous pathological conditions, such as tumors, autoimmune diseases and viral infections. In recent years, numerous studies have assessed the clinical relevance of HLA-G expression in different types of cancer: in general, a higher HLA-G expression correlates with a lower survival rate or a shorter disease-free survival.Altered expression of HLA-G has been found in both HCV and HBV infection, and some genetic polymorphisms have been associated with altered susceptibility/disease development for these infections, however, whether the biologic role of HLA-G in HCV and HBV infection is beneficial or hazardous, it is not completely clear. In the context of hepatocellular carcinoma, HLA-G has shown a potential diagnostic role, moreover a prognostic value in HCC patients has been also attributed to HLA-G molecules.We revise here the role of HLA-G in hepatotropic HBV/HCV infections and in hepatocellular carcinoma (HCC).
KW - HBV
KW - HCV
KW - Hepatocellular carcinoma
KW - HLA-G
UR - http://www.scopus.com/inward/record.url?scp=84927572661&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84927572661&partnerID=8YFLogxK
U2 - 10.1016/j.humimm.2014.09.019
DO - 10.1016/j.humimm.2014.09.019
M3 - Article
C2 - 25318079
AN - SCOPUS:84927572661
VL - 75
SP - 1225
EP - 1231
JO - Human Immunology
JF - Human Immunology
SN - 0198-8859
IS - 12
ER -