Non coding RNA and brain

Carlo Presutti, Jessica Rosati, Sara Vincenti, Sergio Nasi

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Small non coding RNAs are a group of very different RNA molecules, present in virtually all cells, with a wide spectrum of regulatory functions which include RNA modification and regulation of protein synthesis. They have been isolated and characterized in all organisms and tissues, from Archaeobacteria to mammals. In mammalian brain there are a number of these small molecules, which are involved in neuronal differentiation as well as, possibly, in learning and memory. In this manuscript, we analyze the present knowledge about the function of the most important groups of small non-coding RNA present in brain: small nucleolar RNAs, small cytoplasmic RNAs, and microRNAs. The last ones, in particular, appear to be critical for dictating neuronal cell identity during development and to play an important role in neurite growth, synaptic development and neuronal plasticity.

Original languageEnglish
Article numberS5
JournalBMC Neuroscience
Volume7
Issue numberSUPPL. 1
DOIs
Publication statusPublished - Oct 30 2006

Fingerprint

Small Untranslated RNA
Untranslated RNA
Neuronal Plasticity
Small Cytoplasmic RNA
Small Nucleolar RNA
RNA
Archaea
Brain
Neurites
MicroRNAs
Growth and Development
Mammals
Learning
Proteins

ASJC Scopus subject areas

  • Medicine(all)
  • Clinical Neurology
  • Neuroscience(all)
  • Cellular and Molecular Neuroscience

Cite this

Presutti, C., Rosati, J., Vincenti, S., & Nasi, S. (2006). Non coding RNA and brain. BMC Neuroscience, 7(SUPPL. 1), [S5]. https://doi.org/10.1186/1471-2202-7-S1-S5

Non coding RNA and brain. / Presutti, Carlo; Rosati, Jessica; Vincenti, Sara; Nasi, Sergio.

In: BMC Neuroscience, Vol. 7, No. SUPPL. 1, S5, 30.10.2006.

Research output: Contribution to journalArticle

Presutti, C, Rosati, J, Vincenti, S & Nasi, S 2006, 'Non coding RNA and brain', BMC Neuroscience, vol. 7, no. SUPPL. 1, S5. https://doi.org/10.1186/1471-2202-7-S1-S5
Presutti C, Rosati J, Vincenti S, Nasi S. Non coding RNA and brain. BMC Neuroscience. 2006 Oct 30;7(SUPPL. 1). S5. https://doi.org/10.1186/1471-2202-7-S1-S5
Presutti, Carlo ; Rosati, Jessica ; Vincenti, Sara ; Nasi, Sergio. / Non coding RNA and brain. In: BMC Neuroscience. 2006 ; Vol. 7, No. SUPPL. 1.
@article{a0e3e1b667ca44f1b1f2bb9ec2c4fffc,
title = "Non coding RNA and brain",
abstract = "Small non coding RNAs are a group of very different RNA molecules, present in virtually all cells, with a wide spectrum of regulatory functions which include RNA modification and regulation of protein synthesis. They have been isolated and characterized in all organisms and tissues, from Archaeobacteria to mammals. In mammalian brain there are a number of these small molecules, which are involved in neuronal differentiation as well as, possibly, in learning and memory. In this manuscript, we analyze the present knowledge about the function of the most important groups of small non-coding RNA present in brain: small nucleolar RNAs, small cytoplasmic RNAs, and microRNAs. The last ones, in particular, appear to be critical for dictating neuronal cell identity during development and to play an important role in neurite growth, synaptic development and neuronal plasticity.",
author = "Carlo Presutti and Jessica Rosati and Sara Vincenti and Sergio Nasi",
year = "2006",
month = "10",
day = "30",
doi = "10.1186/1471-2202-7-S1-S5",
language = "English",
volume = "7",
journal = "BMC Neuroscience",
issn = "1471-2202",
publisher = "BioMed Central",
number = "SUPPL. 1",

}

TY - JOUR

T1 - Non coding RNA and brain

AU - Presutti, Carlo

AU - Rosati, Jessica

AU - Vincenti, Sara

AU - Nasi, Sergio

PY - 2006/10/30

Y1 - 2006/10/30

N2 - Small non coding RNAs are a group of very different RNA molecules, present in virtually all cells, with a wide spectrum of regulatory functions which include RNA modification and regulation of protein synthesis. They have been isolated and characterized in all organisms and tissues, from Archaeobacteria to mammals. In mammalian brain there are a number of these small molecules, which are involved in neuronal differentiation as well as, possibly, in learning and memory. In this manuscript, we analyze the present knowledge about the function of the most important groups of small non-coding RNA present in brain: small nucleolar RNAs, small cytoplasmic RNAs, and microRNAs. The last ones, in particular, appear to be critical for dictating neuronal cell identity during development and to play an important role in neurite growth, synaptic development and neuronal plasticity.

AB - Small non coding RNAs are a group of very different RNA molecules, present in virtually all cells, with a wide spectrum of regulatory functions which include RNA modification and regulation of protein synthesis. They have been isolated and characterized in all organisms and tissues, from Archaeobacteria to mammals. In mammalian brain there are a number of these small molecules, which are involved in neuronal differentiation as well as, possibly, in learning and memory. In this manuscript, we analyze the present knowledge about the function of the most important groups of small non-coding RNA present in brain: small nucleolar RNAs, small cytoplasmic RNAs, and microRNAs. The last ones, in particular, appear to be critical for dictating neuronal cell identity during development and to play an important role in neurite growth, synaptic development and neuronal plasticity.

UR - http://www.scopus.com/inward/record.url?scp=34948900503&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34948900503&partnerID=8YFLogxK

U2 - 10.1186/1471-2202-7-S1-S5

DO - 10.1186/1471-2202-7-S1-S5

M3 - Article

C2 - 17118159

AN - SCOPUS:34948900503

VL - 7

JO - BMC Neuroscience

JF - BMC Neuroscience

SN - 1471-2202

IS - SUPPL. 1

M1 - S5

ER -